Comments by "" (@DanielSMatthews) on "Upsurge in COVID cases linked to Melbourne Black Lives Matter protests" video.

  1.  @findthefacts8900  That is complete and utter bullshit, they have recovered the actual virus from corpses that were buried in permafrost and sequenced its genetic code, so they know exactly what happened in 1918, so much so that they could recreate that virus if they wanted to do so. In fact they have, then used that to test which genes contributed to it being so harmful. Basler, C F et al. “Sequence of the 1918 pandemic influenza virus nonstructural gene (NS) segment and characterization of recombinant viruses bearing the 1918 NS genes.” Proceedings of the National Academy of Sciences of the United States of America vol. 98,5 (2001): 2746-51. doi:10.1073/pnas.031575198 "The influenza A virus pandemic of 1918–1919 resulted in an estimated 20–40 million deaths worldwide. The hemagglutinin and neuraminidase sequences of the 1918 virus were previously determined. We here report the sequence of the A/Brevig Mission/1/18 (H1N1) virus nonstructural (NS) segment encoding two proteins, NS1 and nuclear export protein. Phylogenetically, these genes appear to be close to the common ancestor of subsequent human and classical swine strain NS genes. Recently, the influenza A virus NS1 protein was shown to be a type I IFN antagonist that plays an important role in viral pathogenesis. By using the recently developed technique of generating influenza A viruses entirely from cloned cDNAs, the hypothesis that the 1918 virus NS1 gene played a role in virulence was tested in a mouse model. In a BSL3+ laboratory, viruses were generated that possessed either the 1918 NS1 gene alone or the entire 1918 NS segment in a background of influenza A/WSN/33 (H1N1), a mouse-adapted virus derived from a human influenza strain first isolated in 1933. These 1918 NS viruses replicated well in tissue culture but were attenuated in mice as compared with the isogenic control viruses. This attenuation in mice may be related to the human origin of the 1918 NS1 gene. These results suggest that interaction of the NS1 protein with host-cell factors plays a significant role in viral pathogenesis."
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