Comments by "Vary Olla" (@varyolla435) on "Polio: The Disease that Paralyzed the World" video.

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  22. Actually the risk of developing cVDPV has been known for decades. Any time you use an attenuated vaccine on a mass level then given the idiopathic variance seen in populations there is always a risk a number might fail to defeat the weakened organism as expected to subsequently develop a "subacute infection". What matters is the risk of this happening is infinitesimal. For these rare cases to then go on to infect others is even more remote and requires above all else = an unvaccinated population. If a person develops a mild case of what a vaccine works against and they are surrounded by vaccinated - it usually stops with them. If however said person is around lots of unvaccinated = the virus now has a reservoir from which to spread. Moral of the story: in the case of Poliovirus it can exist in the environment for up to 2 months + it is spread via the GI tract. In other words people use the bathroom to contaminate their sewage systems + they don't wash their hands to spread it around + if they have common water systems such as poor villages which use wells etc. they can further contaminate those = all of which can potentially infect another if as noted above they also are not vaccinated. So the recent instances of cVDPV noted of late occurred in communities with high levels of unvaccinated owing to religious objections. Had they been vaccinated then there would have likely been no spread. Actual cases of cVDPV are 1 out of millions of doses of OPV administered. The WHO and NGOs have encouraged poorer nations to stop using OPV for years and to switch to IPV - which costs more. cVDPV can not happen with the IPV vaccine. 🤔
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  30.  @stephaniegormley9982  You are misinterpreting what is said and missing the obvious. 1 - Polio exists in the environment as I noted = specifically contaminated water sources. 2 - passive immunity from the mother to infant does not last. In so much as an infant must be exposed + that exposure occurs from their environment = timing of exposure does not matter as the problem is not "when" a child is exposed - but that they are exposed in the first place. 3 - Polio typically elicits what Salk alluded to. Some - REGARDLESS OF AGE OF EXPOSURE - will become infected yet will only incur mild symptoms. Some however will progress to the more severe form of the disease resulting in neurological involvement. Moral of the story: so the solution here was vaccination as the cause of Polio was infected people who contracted Poliovirus from their environment to re-contaminate the same. To assume an infant being exposed "hopefully" acquiring the mild form of Polio via maternal immunoglobulins lending to a possible reduction in incidence down the line is an unwarranted assumption. Despite improvements on sanitation Polio persisted. Upon the advent of a vaccine incidence of Polio dropped like a stone so that today is it virtually gone now from the world. "Wild" Polio today only exists in the mountainous regions of Afghanistan and Pakistan where conflict and the tribal nature of the areas prevent vaccination efforts. So the cure to Polio was never sanitation and it continued to persist before and after sanitation improved in many places. The cure was vaccination.
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  74. Not necessarily. You are generalizing on what is actually a multi-factorial process. How long a countermeasure like a vaccine takes to develop is contingent upon what is known about the pathogen + how it acts in the body + and any previously existing technology which can be applied towards a new application. Here are 2 examples: 1 - the HIV virus attacks your immune system itself. You meanwhile rely upon that immune system = to defeat infectious pathogens. So it is exceedingly difficult to craft a vaccine - which requires your immune system to work - when what is being defended against disables that same immune system. Thus 40 years later = no viable HIV vaccine as yet. 2 - when the Model T Ford first came out it was years later before new model automobiles began to be produced. Today meanwhile mechanical engineers can push out new model cars sometimes every year or two = how??? Answer: by applying what was known from previous automobile technologies and adapting that to some new variation...........so it is with vaccines. Moral of the story: if you understand the structure of a virus and what part it uses to attack your cells - called antigens + you are able to replicate those in some form either via artificially reproducing them in a lab or modifying a "vector" via CRISPR to manifest those antigen structures = you can plug that into some "vaccine model" based upon previously proven vaccines to yield something which can work. They are not necessarily "starting from scratch" all the time you know. We've learned quite a bit about vaccine development the past 50+ years.
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