Comments by "Roger Scott Cathey" (@rogerscottcathey) on "The New York Times"
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I believe there are options for prevention and treatment that entail two possible approaches: We know the primary avenue of attack are the lungs, and once in, they attach by means of the spicules or "spikes". Their primary target or "receptor" are the ACE-2 or angiotensin-converting enzymes, same as that of SARS-CoV, on the epithelial cells of the lungs. Right there is one strategy for a form of intervention using nebulized or detached bonding receptors, akin to chelators or in fact serpins, serine protease inhibitors.
Beside Remdesivir, Pyridone type, and specifically an alpha-ketomide inhibiting compound "13b" will likely emerge as promising along these lines within the body. This compound disables the sars-cov-2 cleavage enzyme on the attachment spikes (TMPRSS2 transmembrane serine protease).
Since this is a papain-like enzyme, the inhibitor will not affect the human serine enzymes, like trypsin, amylase, etc.
It could be used externally as well to attach aerosolized virii and they'll be inactivated even if they are inhaled.
Paper on Alpha-ketomide inhibitor Compound 13b:
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors
Linlin Zhang
Daizong Lin
Xinyuanyuan Sun
Ute Curth4, et als.
https://science.sciencemag.org/content/early/2020/03/20/science.abb3405.full
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Another approach is in terms of direct digestion of the virus by hydrolases like amylase, trypsin, chymotrypsin, carboxypetidase, lipase and most importantly RNAase. Intramuscular injections of amylase and trypsin were proven to resolve malaria very effectively by Lambelle in the early part of the 20th c. The ratio of amylase to trypsin was 2:1, and was well tolerated. His paper is available as a link below. While malaria is not a virus, the process of infectant inhibition of native enzymes taxing the whole system is akin and the strategy of bolstering it is rational. Futhermore the glycoprotein of the viral spike is very susceptible to degradation by amylase which enables full access of the pancreatic proteases or their serum analogs.
It is worthwhile to also research the potential of external nebulized colloidal silver in air systems and bound to fiber masks, as an effective means of external denaturing the virus. As for inhaled nebulized colloidals, I am aware of only one article on an inhalant or in nebulized form:
Journal of Nutritional & Environmental Medicine:
Viral Pathogens and Severe Acute Respiratory Syndrome: Oligodynamic Ag+ for Direct Immune Intervention
Eric Rentz Do Comm Cnmo
https://www.tandfonline.com/doi/abs/10.1080/13590840310001594061
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For structure of viral components, also see:
Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein
Authors:
Alexandra C.Walls
David Veesler
https://www.sciencedirect.com/science/article/pii/S0092867420302622
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A transcription I did of Dr. Lambelle's paper on malaria treatment using amylase and trypsin is available at a mirror of my old website:
https://robertcathey.wordpress.com/the-utility-of-enzymes-in-malaria-by-f-w-lamballe-m-b-major-royal-army-medical-corps/
Lambelle, F. W. (1913). Journ. R.A.M.C., Vol. XXI, p. 660.
John Beard's letter to Nature re Dr. Lambelle's work. (The transcriptionist at Nature misspelled Lambelle as "Lamballe".)
https://www.nature.com/articles/092060c0
(edit 4/9/2020)
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Here, research away.
The current lockdowns and compulsory masking are not based on science. Even the term "social distancing" is not science terminology, it is psy-op terminology.
Physical distancing is the traditional medical term used in preventive and safety measures against viral spread and is the correct terminology. "Social distancing" is a loaded term. Its advocation expresses isolation and ostracization, implies powerlessness, capitulation, obedience and fear. It is a politically loaded and tactical term.
The science on masks is irretrievably divided as to effectiveness. Serious studies have shown even masks in surgeries have equivocal results. In other words, no proof mask wearing in ORs saves lives or prevents post-op infections. More likely culprits suspected are insterile, i.e. un-sterile, OR's or post-surgical infection from other sources. Indeed, one study suggests masks increase problems in ORs. (links below). Still, an obviously problematic area for controlled study.
We dont need any vaccine for this politically exacerbated and stimulated scourge anyway.
The greatest harm being done right now is due to the abysmal and seemingly intentional ignoring of the almost miraculous effectiveness of Ivermectin against sars-coV-2 disease.
I think there is little doubt this neglect and suppression of the news of Ivermectin is intentional. It competes with the bigger money maker, or the bigger tax write off, for big pharmas like Pfizer and others of their putative 90% effective vaccine.
Listen to this story from Dr. Jennifer Hibberd regarding the serendipitous discovery that Ivermectin would end up saving the lives of an entire Canadian nursing home population from a covid-19 outbreak. Ivermectin was being used to treat an outbreak of scabbies prior to the covid-19 outbreak in the rest home. As a result of their use of Ivermectin, No resident became seriously ill.
And yet! the nurses did come down ill, because they were NOT taking Ivermectin. That's how it was known sars-coV-2 was active there. It was an unintentionally controlled study! All residents were elderly with co-morbidities. All survived.
The second link below is an interview with Dr. Thomas Borody regarding the success of his tri-therapy of Ivermectin, zinc and doxycycline. But to reiterate, the Nursing home story shows that Ivermectin alone does the job just fine.
Dr. Hibberd:
https://youtu.be/8XCYzpHBEkI
Dr. Borody on Ivermectin tritherapy.
https://youtu.be/PyA_FlPCWUA
Re: Mask, respirators, etc. Shows how equivocal the evidence is.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191274/
Another link resource pointed to more for article links than over-all opinion. One must know the range of data and draw personal opinion. It is quite obvious home made cloth masks are merely appearances, need to be washed daily at least, optimally several times a day.
https://www.rcreader.com/commentary/masks-dont-work-covid-a-review-of-science-relevant-to-covide-19-social-policy
Mask redux 3:
I have expanded links below in my comment for further scholarly articles.
I have pointed out science literature to show, just as Fauci showed by his initial position, there is scientific uncertainty regarding this issue. If you read the following papers, you'll realize that studies and articles are plentiful.
Mask wearing is not on the same level of science as sterile hand contact with internals, as in a delivery, a laparotomy or even excision of a mole. Laymen can be forgiven for ignorance of this topic and this issue, but scientists should know better. The public servants have chosen to ignore it evidently out of liability concerns more than anything else. Only it may actually do the reverse of what they expect.
As for why masks are still worn in surgeries: liability issues, whether or not the operating room, instruments or personnel had anything to do with a post-op infection, the effectiveness or not of masks is irrelevant, but exists as a weak point in a defense against a tort. Here is a relevant quote:
"Examination of the literature revealed much of the published work on the matter to be quite dated and often studies had poorly elucidated methodologies. As a result, we recommend caution in extrapolating their findings to contemporary surgical practice. However, overall there is a lack of substantial evidence to support claims that facemasks protect either patient or surgeon from infectious contamination. More rigorous contemporary research is needed to make a definitive comment on the effectiveness of surgical facemasks."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480558/
Well other more rigorous studies were done.
The Studies of Surgical Mask Efficacy -- Arthur Firstenberg
http://12160.info/m/blogpost?id=2649739:BlogPost:2035264
https://muchadoaboutcorona.ca/face-masks-cause-wound-infection/
The following provide links to download pdfs of articles, no fee.
Neil W.M. Orr, Six month study of maskless surgery
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493952/
PubMed Orr article:
https://pubmed.ncbi.nlm.nih.gov/19310816/
Goggles more important than masks
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1964349/
Springer open source article
on mask study -- Tunevall
https://link.springer.com/article/10.1007/BF01658736
Most medical journals now provide scholarly articles relating to covid free of charge at the present time.
We conceived a simple way to dispense with the issue by operating with an air hose over the back through silver ion sterilizing filters, an adaptation of the solution C.L. Kervran developed for reducing carbon monoxide poisoning to welders by breathing heated air while annealing iron plates.
As to double blind, placebo controlled studies, this is not needed with Ivermectin, with a proven history of effectiveness, known LD50s, optimal dosages, etc. To say nothing of the immorality of such time wasting efforts. Dr. Borody compares that to the ridiculousness of such study on parachutes. Dead weight studies were sufficient to prove efficacy. First human tests were always done with safety protocols, over water, nets, etc. None were done for some jumping with, some jumping without parachutes or different parachutes. Linear comparatives or longitudinal studies were done of course, and improvements adopted.
Regarding Ivermectin Prophylaxis, i.e. preventive efficacy:
https://clinicaltrials.gov/ct2/show/results/NCT04422561
White Board Channel re above study:
https://youtu.be/TmzvDa9Un44
https://www.youtube.com/c/WhiteboardDoctor
Dr. Borody re: controlled study of Ivermectin:
https://youtu.be/POfIMGS2D6A
The British Medical Journal on Randomized, controlled study of Parachutes to prevent death and injury. Seriously, not an April 1st release!
https://www.bmj.com/content/363/bmj.k5094
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@manuelashka07 : Aspirin was meant only for pain. Now we see so-called off-label functionality of this acid. It has preventive properties towards colon cancer, heart disease, even can cure ring worm topically. Dr. Borody is a full M.D. and has ties to the Mayo Clinic and studies under his counsel are going forward in hundreds of studies. But, as I said, the use of Merck's IVM has been around a long time, and people using it for various reasons have ben spared the serious complications that causes death in most cases. It is irrelevant now what its traditional uses may have been. True medicine is empirical and pragmatic: whatever works. And it works. Borody has innovated "combination therapy" or tri-therapy that proved so effective in many different diseases. Even now evidence suggests that the many carriers of sarscov2 who didnt even know they had it, had higher titers of vitamin D and zinc in their systems than those who fell ill with like viral loads. The evidence is overwhelming that the extent of infection is much higher than those deemed cases or requiring hospitalization. What has made the difference? Obviously not IVM, but vitamin and mineral levels are common differences. IVM is a prophylactic, a preventative stop gap. Like a fire break. And, it does cure the disease in even advanced cases as well as cure can be defined. Once well from this strain, that strain will not recur. Variants might arise, but the same drastic surge will not.
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