Comments by "Jake Johnson" (@ElectronFieldPulse) on "Heme Review" channel.

@zachgman - Well, yes, any modulator would have to bind to take effect.
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@zachgman - Aren't benzodiazepenes allosteric modulators? They stabilize a configuration of the GABA receptor that is more stable when being bound by endogenous GABA molecules, basically making the bound state more energetically favorable, which means the receptors are activated more. I have also heard there are benzo receptors though, so I am guessing it is also a full agonist in addition to being an allosteric modulator. Does that sound right or am I off? I haven't read up on that for 10 years or so.
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@zachgman - This is off the top of my head, so don't take it as gospel, but I think it's right. So, certain neurons have benzodiazepene receptors in the brain. Once activated, these receptors cause the accumulation of GABA neurotransmitters and an uptick in free floating dopamine in the nucleus accumbens. So, your brain has specific receptors for it, but your body also has GABA receptors literally everywhere. It is one of the main neurotransmitters. So, benzos probably bind directly in the brain in order to produce the alterations in mood, but they bind allosterically throughout much of the body to generally increase the inhibitory neurons firing, which makes the body slow down overall. This is why they work as muscle relaxers as well. Now, I am not 100% sure this is the case, but I think this is what was taught to me in biochem 431.
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@zachgman - Also, I like you too! It's always nice to have a civil conversation on here
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@zachgman - No problem, it was a pleasure. Take care! As a side note, isn't it weird you can have meaningful conversations with people you have never heard of, only to never talk to them again in your life? Our social dynamics are profoundly different than a peasant from 300 years ago that only talked to the 30 people in his village that he knew his entire life. Sorry, just got off work and did some delta 8 to relax. Makes me think of tangential material.
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Cancer is not one disease, it is a bunch of different disorders. So no one solution will work.
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@ArtisticFreedom - I knew a person who had sickle cell anemia who was selling liquid oxycodone. I didn't understand it, if you get that strong of shit, wouldn't you need it?
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@zachgman - Yes, you are correct, I just think that people automatically assume that given the dependent nature of allosteric modulators and how they work. Not much good on their own.
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@Dexter Antonio - Yep. I have a biochem degree and I am only making 55k year as a research chemist. Smart enough to graduate with a degree in biochem, dumb enough to choose it in the first place.
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