Youtube comments of (@chubbyemu).

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  72. Happy Medical Monday! (which isn’t every Monday) Music by Lifeformed: https://lifeformed.bandcamp.com 1. I’ve seen laxative overdose a few times in the ER. BG is a real person, who was 14 in December 2010. His behavior is not limited to people aged 14.. Anecdotally worse in ages just a little older. Goes without saying… don’t take more than recommended amount of laxative or any other over the counter drug. 2. Timescale’s a bit unclear, as is case with most patient reports. 3. 2:25 Calf muscle is a prominent area of muscle pain in this condition. 4. 3:38 Potassium is scarce extracellularly compared to sodium. It’s the principal intracellular cation. 5. 3:51 “why don’t you talk about calcium in muscle contraction?” Because the rabbit hole will go too far in and I got into a version of the video that became a clinical lecture. Original draft of this video was 35 minutes long, given the nature of what happens with kidneys and calcium. 6. 4:30 More than just potassium is given. It’s the 3rd or 4th in sequence I believe. 7. 4:45 this is a type of ventricular tachycardia (ventricle = chamber of the heart, tachy = fast, cardia = heart rate) called torsades de pointes. It’s lethal, usually arises from QT prolongation. For hypochondriacs out there, you probably don’t have it right now. 8. 5:36 Another rabbit hole. Actually calcium is allowed in too, leads to more muscle contraction, and calcium deposits in tissue which appear in imaging. Hypocalcemia then leads to higher phosphate levels, increasing bone resorption, breaking bones, damaging kidneys, etc. This part of the video could go on for hours. 9. 6:09 Think about 6 2L bottles of soda swelling up in your muscles. That’s a lot of water. 10. 6:30 If you want to know more about this, there’s hormones at play here, but medicines can also constrict afferent and efferent arterioles. 11. 8:12 The real BG did have myoglobinuria. 12. 8:45 That’s a bottle of lactic acid. Same thing that makes your muscles sore after exercise. Since muscle is breaking down, it spills into blood, releasing H+ causing acidosis. 13. 9:15 Sorry music is loud… 14. 11:20 What would we give him for metabolic acidosis? Comment below :) 15. Quail by KaouroV
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  84. who needs they shrussy ate? 🍄👁👄👁 The FDA just sent a letter out re: Amanita muscaria as I post this video in December 2024, saying "Amanita muscaria, its extracts, and certain constituents (muscimol, ibotenic acid, and muscarine), when used or intended for use in conventional food, are unapproved food additives. Food containing such ingredients is adulterated under the Federal Food, Drug, and Cosmetic Act (FD&C Act) and are subject to enforcement action.” https://www.fda.gov/food/post-market-determinations-use-substance-not-gras/letter-industry-use-amanita-muscaria-or-its-constituents-food Here’s some personal commentary: This letter comes as a response to recent situations: the Morbidity and Mortality Weekly on 18 July 2024 (the one from this video when I mentioned Gas Station Mushroom Edibles) and from the “microdose edibles” 2024 recall, also mentioned in the video. In both of those situations, more than just Amanita muscaria chemicals (Ibotenic Acid, Muscimol, Muscarine) were found by laboratory, if they were found at all, in the products. So, if these products were supposed to be Amanita muscaria edibles, but weren’t, then that really sucks that Amanita muscaria is taking the fall for this. Letter aside, from a personal standpoint you should be aware of what the actual Amanita muscaria mushroom’s impact on you can be. Everything that goes into your body has a benefit-to-risk assessment. Be wary of composite products. Be reasonable, take care of yourself, and be well!
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  1008. ive been sitting on this comment for a little bit to think. before you think about having the personality of becoming a surgeon (which is very important) you have to know the system in which you're operating. If you're in the United States, the barrier to entry is about the highest it can be for a (typically) non-famous, non-leadership role. you first need to finish a 4 year college degree with medical school prerequisites, get very high grades, volunteer and be in student organizations, etc. then you need a high score on your MCAT and interview well to get into medical school. after you get in, at the end of your second year you have to take step 1 exam for your medical licensure. surgeons typically score very, very high for that exam. scoring low can bar you from entering surgery. after that, you need to match a residency before you finish medical school. surgery post-graduate training typically lasts anywhere from 5-12 years after medical school meaning you'll likely be in your mid-late 30s when you become attending physician. no doubt, it's a system that works against the common person. so i am not trying to scare you from pursuing that dream, but those are the systemic things that are required. personality to achieve those develop on you over time. when i was younger, i used to grit my teeth and tell myself i liked things, even though i didnt like what i was doing that moment. when you're getting started in anything, you need to do things you dont want. you have to love the outcome of your work because the path to that outcome is always difficult. even your dream job will have day to day doings that you won't enjoy. hope this helps.
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  1283. yes. a problem in medicine is that new practitioners now coming out of school have been indoctrinated with the "we know better for everyone than they do for themselves" mentality, but practitioners have been marginalized politically, so they subject themselves to meaningless little issues like this. the other thing too is looking at the authors of the paper, the first author is a 2nd year pharmacy resident. one issue I've seen with pharmacists is a strange desperation to legitimize their profession using narrowly-scoped situations like this that inevitably stick them to mundane tasks and take them further away from patient care. pharmacists do not have provider status under medicare, meaning they have much less privilege under the system, and have been fighting for it for more than a decade, but they have little congressional voice due to several issues inside the profession. meanwhile, politicians have out-maneuvered physicians, and physicians can now no longer act in the interest of the patient but instead in the interest of reimbursement schemes dictated by the government. look up outcomes-based reimbursement and heart attack. if someone goes to the hospital for a heart attack and is successfully treated, BUT within 30 days is readmitted for another heart attack, the hospital doesnt get paid for either admission. but what if it was the patient's fault for not taking their medicine post-heart attack? since that will happen in every hospital every year, the prices of other services goes up. but what if all other services are subject to outcomes based reimbursement? this system is cannibalizing itself at the expense of ordinary people and people who really need the help like you
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  1556. to your last point, being on truvada without the pre-exposure prophylaxis indication would mean the person is already infected, so yes they should be banned from donating blood. truvada suppresses viral load but does not eliminate it. that is clearly stated in the package insert. but even with pre-exposure prophylaxis, suppose every single HIV-infected partner were on dual use of condom and antiretroviral. 0.8% of 1.38% is still 0.011%. When your risk population is at 13M (as noted in the video), that's still on average 1,435 people who will get infected. Given there is a 92.5% chance of infection from blood transfusion, 1,328 people will still get infected from the blood. this is using the hard assumption of constant infection rates, a non-growing population, and that all gay men would give blood. in the case for public health, you should overestimate and assume the maximum number. How about when those 1,328 get infected without knowing it for a year, and spread it through sexual contact? there'd be a disaster. even with a 0.011% chance, if the partners were monogamous but one was infected, we still could not detect the HIV without some time window >~months to allow for viral incubation and antibody formation. your first points: tops still have an infection rate and is still greater than that of any kind of heterosexual sex-- i said it in the video. no way to prove monogamous long term relationships (same with straight people, but the population size 96 vs 4% dilutes the risk significantly). for oral sex only the study states it had a sample size of 8965 acts, which is too small a sample size compared to other sexual events to make a determination. once a blood supply is exposed as tainted, it is all destroyed, which makes the situation worse given we are short. the public panic and burden on the healthcare system if even 100 patients were found to be infected via HIV-infected blood outweighs the benefit of the additional donations. it's political suicide for anyone inside the FDA, CDC to lift this, which is a different topic altogether. the homophobic label and divisive rhetoric adds literally nothing to the conversation to this difficult decision and blinds people from the evidence we have.
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