Comments by "Pottenger\x27s Human" (@LTPottenger) on "Stay Young Forever: The #1 Thing For Overall Health u0026 Longevity Is This... | Peter Attia" video.

  1. The best thing you can do for longevity is do some extended fasting and lower your carb intake. Glycation is one of the biggest drivers of aging and fasting reverses this and stimulates your body's repair mechanisms. Some benefits of doing occasional extended fasting: High blood pressure is lowered to normal levels very quickly while fasting. Fibrosis/scarring is reversed over time, including in the heart and lungs. Fasting stimulates phagocytosis, the ingestion of bacteria, plaques and viruses by the immune system. It will also remove any 'foreign material' like spikes that are not supposed to be there. Whether natural or unnatural in origin.. Blood clotting is reduced and blood clots and arterial plaque are reabsorbed into the body. Blood sugar and insulin are lowered when fasting, allowing white blood cells to move more freely throughout the body and do their job. Vitamin D plasma levels are increased as fasting improves metabolic health, and vitamin D in turn increases autophagy. Fasting increases nitric oxide release. Fasting restores NAD+ to healthy levels. Reflexes and short term memory are increased. Telomeres are lengthened and fasting also increases anti-aging Yamanaka factors. After 72 hours or more fasted, your body recycles up to 1/3 of all immune bodies, rejuvenating your entire immune system. This helps prevent the onset of new autoimmune conditions, which develop through a leaky gut and damaged immune system. Fasting can help with MS, Depression, BPD, Autism and seizures. Thymus is regenerated, which suppresses aging and renews the immune system. The thymus also plays a vital role in fighting cancer. Weight loss from daily caloric restriction has 1/4 to 1/3 of the weight lost as lean tissue while many studies show fat loss from 36 h fasts without losing any lean tissue! The obese will lose extra tissue like loose skin while fasting, but the skinny or frail will have increased growth hormone release than the obese, which helps to make more lean tissue and reduce frailness. When you move out of MTOR your body shuts down the building blocks of the cell required for viruses to replicate. The hunger hormone ghrelin also lowers with extended fasting and rises from dieting. What breaks a fast? Anything with protein or carbohydrates in it will break a fast. Most teas and herbs are OK. Most supplements and meds will either break ketosis directly or contain a filler that will. Many meds are dangerous to take while fasting. Does fasting lower testosterone? No, it raises it when the fast is broken by increasing lutenizing hormone. Fasting also increases insulin sensitivity, which helps with muscle building. Fasts of 36-96 will not affect short term female fertility or affect menstrual cycle. They also may increase long term fertility, especially in women with PCOS. Fasting reduces pain and anxiety by stimulating the endocannabinoid system in a similar way to CBD oil. One day of fasting can cut your leptin levels in half and gets your immune system working properly again! This reduces leptin resistance, which impairs immune function. Stomach acid is reduced over time while fasting and can allow for the healing of treatment resistant ulcers. Some patients may need continued acid reduction medication while fasting. Does the body preferentially prefer glucose as a fuel? No. Except for brief periods of very intense exercise, your body mainly burns fats in the form of free fatty acids. Your brain also prefers to burn ketones at a rate of around 2.5 to 1 when they are available in equal quantity to glucose. Fasting stimulates the AMPK complex and activates autophagy. Autophagy (literally self eating) will cause cells to recycle damaged proteins and foreign matter such as viruses. It will can kill cancerous and senescent cells It increases mitochondrial function and repairs mitichondrial DNA, leading to improved ATP production and oxygen efficiency. Increased mitochondrial function also has the added benefit of increasing your metabolism, fighting infection and cancer prevention! Fasting releases BDNF and NGF in the blood which stimulates new nerve and brain cell growth. This can help a great deal with diseases like MS, peripheral neuropathy and Alzheimers. When not in ketosis, the brain can only burn carbohydrate, which produces a great deal of damaging ROS the brain has to deal with. Fasting also increases telomere length, negating some of the effects of aging at a cellular level. When you fast, this stimulates apoptosis in senescent or genetically damaged cells, destroying them. Senescent cells are responsible for many of the effects of aging and are a root cause of the development of cancer. A fasting mimicking diet for 3-5 days in a row also provides many of the same benefits as water fasting. FMD usually has 200-800 calories, under 18 g of protein and extremely low carbs. Exogenous ketones can aid with fasting, making it easier in healthy people and allowing some people with specific issues to fast in spite of them without worrying as much about hypoglycemia. They also help with dementia and many other issues even if you take them while not fasting! Glycine and trimethylglycine can also be useful supplements while fasting that won't break ketosis and have many benefits. Children, pregnant or nursing women should not fast for periods longer than 16 hours. People with pancreatic tumors or certain forms of hypoglycemia generally cannot fast at all. Type 1 diabetics can also fast but it is more complicated and should be approached with caution as it could lead to ketoacidosis. If you experience extreme symptoms of some kind, especially dizziness or tremors, then simply break the fast and seek advice. Resources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783752/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1413655/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783752/ https://pubmed.ncbi.nlm.nih.gov/6859089/ https://www.ncbi.nlm.nih.gov/pubmed/10232622 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470960/ https://www.sciencedirect.com/science/article/pii/S1931312809002832 https://pubmed.ncbi.nlm.nih.gov/15522942/ https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.2019.33.1_supplement.819.10 https://www.biorxiv.org/node/93305.full https://www.arcjournals.org/pdfs/ijrsb/v3-i11/7.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407435/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141719/ https://pubmed.ncbi.nlm.nih.gov/20921964/ https://pubmed.ncbi.nlm.nih.gov/25909219/ https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30605-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1097276518306051%3Fshowall%3Dtrue https://pubmed.ncbi.nlm.nih.gov/28235195/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815756/ https://www.nia.nih.gov/news/research-intermittent-fasting-shows-health-benefits https://medicalxpress.com/news/2022-10-treatment-pulmonary-fibrosis-focus-telomeres.html https://www.ncbi.nlm.nih.gov/pubmed/10859646 https://academic.oup.com/ajcn/article/81/1/69/4607679 https://pubmed.ncbi.nlm.nih.gov/31877297/ https://n.neurology.org/content/88/16_Supplement/P3.090 https://pubmed.ncbi.nlm.nih.gov/31890243/ https://pubmed.ncbi.nlm.nih.gov/2518860/ https://www.ncbi.nlm.nih.gov/gene/25712 https://pubmed.ncbi.nlm.nih.gov/23707514/ https://www.ncbi.nlm.nih.gov/pubmed/24905167 https://www.health.harvard.edu/heart-health/abundance-of-fructose-not-good-for-the-liver-heart https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093158/ https://clinical.diabetesjournals.org/content/36/3/217 https://www.ncbi.nlm.nih.gov/pubmed/23876457 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526871/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607739/ https://pubmed.ncbi.nlm.nih.gov/29727683/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895342/ https://www.ncbi.nlm.nih.gov/pubmed/25686106 https://pubmed.ncbi.nlm.nih.gov/21410865/ https://www.collective-evolution.com/2017/05/16/study-shows-how-fasting-for-3-days-can-regenerate-your-entire-immune-system/ https://pubmed.ncbi.nlm.nih.gov/7714088/ https://www.cell.com/cell/fulltext/S0092-8674(19)30849-9 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017674/ https://pubmed.ncbi.nlm.nih.gov/23408502/ https://www.amjmedsci.org/article/S0002-9629%2815%2900027-0/fulltext https://europepmc.org/article/MED/22402737?javascript_support=no https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2265.2005.02288.x https://www.nejm.org/doi/full/10.1056/NEJMoa012908 https://pubmed.ncbi.nlm.nih.gov/27569118/ http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00224-7 https://repository.upenn.edu/cgi/viewcontent.cgi?article=1537&context=edissertations https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779438/ https://www.nejm.org/doi/full/10.1056/NEJMc2001176 http://www.sciencedirect.com/science/article/pii/S0005272806000223 https://www.clinicaltrials.gov/ct2/show/NCT04375657 https://pubmed.ncbi.nlm.nih.gov/20102774/ This list compiled over years of research by the user known as Pottenger's Human on youtube. Feel free to copy and paste this anywhere you like, no accreditation needed! My community tab will always contain an updated version of this list of fasting benefits. I also have playlists on fasting and health topics.
    34
  2. Yeah that will only take about a year. @kiwiwriter 
    2
  3. You're very welcome! @paulbirkbeck1790 
    1