Comments by "Pottenger\x27s Human" (@LTPottenger) on "Microbiome" video.

  1. Fasting can do a great deal to improve your gut microbiome, including getting rid of the organisms that have become infected by novel disease vectors that most people do not associate with the microbiome! The many benefits of occasional extended fasting and lowering dietary carbs: Your body recycles up to 1/3 of all immune cells in a 72h fast, rejuvenating your immune system. This helps with autoimmune disease, cancers and cytokine storm. Reduces B cells by over half in a single fast, greatly reducing allergic and other autoimmune responses. Fasting and low carb help with POTS, which is driven by high insulin and blood sugar. Clots and plaques are removed over time due to accelerated phagocytosis. Fasting reduces cortisol over time and improves your circadian rhythm. Fasting quickly lowers blood pressure levels. The hunger hormone ghrelin also lowers with extended fasting and rises from dieting. Fasting stimulates phagocytosis, the ingestion of proteins, pathogens and plaques by macrophages and other immune bodies. This will remove spikes quicker, whether natural or unnatural in origin! Blood sugar and insulin are lowered when fasting, reducing inflammation and allowing the immune bodies to move freely through the body. T cells are cruciall in fighting cancer, autoimmune disease and infection. Tthymus generally stops making them with age but fasting releases stem cells, which then can become new T cells. It also releases growth hormone, which regenerates the thymus! When insulin is high, vit D stays locked in the blood cells but fasting quickly lowers it. Vitamin D plasma levels are increased as fasting improves metabolic health, and D in turn increases autophagy. Your brain prefers to burn ketones at a rate of around 2.5 to 1 when equally available to glucose. Except for brief periods of very intense exercise, your body mainly burns free fatty acids. Fasting increases anti-aging Yamanaka factors and increases average telomere length in stem cell pools. Reflexes and short term memory are increased. Fasts from 36-96 h increase metabolic rate due to norepinephrine release!. Fasting increases interferon, which shuts down the ability of viruses to replicate. Fasting does not reduce testosterone over time. It raises it when the fast is broken by increasing lutenizing hormone. It also increases insulin sensitivity, which helps with muscle building. And removes fat, which also increases estrogen in men. Fasting activates autophagy (literally self eating). This recycles damaged proteins and foreign matter such as viruses. Weight loss from daily caloric restriction has 1/4 to 1/3 of the weight lost as lean tissue while many studies show fat loss from 36 h fasts without losing any lean tissue! It increases mitochondrial function and repairs mtDNA. Mitochondrial function also has the added benefit of increasing your metabolism, fighting infection and cancer prevention! 24h of fasting reduces leptin levels by half! This reduces leptin resistance, which impairs immune function. Fasting restores NAD+, reduces NADH and increases nitric oxide release to open blood vessels. Over time fasting normalizes stomach acid levels and during the fast acid levels go down to allow for the healing of ulcers. Fasting reduces pain and anxiety by stimulating the endocannabinoid system, just like the effect of CBD oil The obese will lose loose skin while fasting, but the frail will have increased growth hormone release, which helps to make more lean tissue and reduce frailness. When not in ketosis, the brain can only burn glucose, which produces a great deal of damaging ROS the brain has to deal with. Fasts of 36-96 will not affect short term female fertility or affect menstrual cycle. They also may increase long term fertility for some women. Fasting increases telomere length, negating some effects of aging at a cellular level. Fasting releases BDNF and NGF in the blood, creating new nerve and brain cell growth. This helps a great deal with diseases like MS, peripheral neuropathy and Alzheimers. Fasting stimulates apoptosis in senescent or genetically damaged cells, destroying them. Senescent cells are responsible for many of the effects of aging and are a root cause of the development of cancer. Glycine and trimethylglycine (TMG) can also be useful supplements while fasting that won't break ketosis and have many benefits. What breaks a fast? Anything with protein or carbohydrates in it will break a fast but most teas and herbs are OK. Supplements and meds usually break ketosis due to fillers or directly. Some of them also irritate the stomach. Many meds are dangerous to take while fasting. Exogenous ketones can aid with fasting, allowing some people with specific issues to fast in spite of them without worrying as much about hypoglycemia. They also help with dementia and many other issues even if you take them while not fasting! Children, expecting or nursing women should not fast for periods longer than 16 hours. People with pancreatic tumors that excrete insulin or certain rare forms of hypoglycemia generally cannot fast at all or only with doctor supervision. T1 diabetics can also fast but it is more complicated and should be approached with caution as it could lead to ketoacidosis and done under doctor supervision. If you experience extreme symptoms of some kind, especially dizziness or tremors, then simply break the fast with a low carb meal. Resources: https://www.nia.nih.gov/news/research-intermittent-fasting-shows-health-benefits https://pubmed.ncbi.nlm.nih.gov/31890243/ https://pubmed.ncbi.nlm.nih.gov/2518860/ https://www.cell.com/molecular-cell/fulltext/S1097-2765(18)30605-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1097276518306051%3Fshowall%3Dtrue https://pubmed.ncbi.nlm.nih.gov/28235195/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815756/ https://medicalxpress.com/news/2022-10-treatment-pulmonary-fibrosis-focus-telomeres.html https://www.cell.com/cell/fulltext/S0092-8674(19)30849-9 https://clinical.diabetesjournals.org/content/36/3/217 https://www.ncbi.nlm.nih.gov/pubmed/25686106 http://www.sciencedirect.com/science/article/pii/S0005272806000223 https://www.ncbi.nlm.nih.gov/pubmed/23876457 https://www.sciencedirect.com/science/article/pii/S1931312809002832 https://www.ncbi.nlm.nih.gov/pubmed/10859646 https://www.amjmedsci.org/article/S0002-9629%2815%2900027-0/fulltext https://www.collective-evolution.com/2017/05/16/study-shows-how-fasting-for-3-days-can-regenerate-your-entire-immune-system/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607739/ https://pubmed.ncbi.nlm.nih.gov/31877297/ https://www.ncbi.nlm.nih.gov/gene/25712 https://pubmed.ncbi.nlm.nih.gov/33530881/ https://www.biorxiv.org/node/93305.full https://www.health.harvard.edu/heart-health/abundance-of-fructose-not-good-for-the-liver-heart https://pubmed.ncbi.nlm.nih.gov/25909219/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783752/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1413655/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783752/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470960/ https://europepmc.org/article/MED/22402737?javascript_support=no https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2265.2005.02288.x https://academic.oup.com/ajcn/article/81/1/69/4607679 https://www.ncbi.nlm.nih.gov/pubmed/24905167 https://www.nejm.org/doi/full/10.1056/NEJMc2001176 https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.121.17852 https://www.clinicaltrials.gov/ct2/show/NCT04375657 https://pubmed.ncbi.nlm.nih.gov/20102774/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407435/ https://pubmed.ncbi.nlm.nih.gov/7714088/ https://www.nejm.org/doi/full/10.1056/NEJMoa012908 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141719/ http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00224-7 https://repository.upenn.edu/cgi/viewcontent.cgi?article=1537&context=edissertations https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779438/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526871/ https://pubmed.ncbi.nlm.nih.gov/23707514/ https://pubmed.ncbi.nlm.nih.gov/20921964/ https://pubmed.ncbi.nlm.nih.gov/29727683/ https://www.arcjournals.org/pdfs/ijrsb/v3-i11/7.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093158/ https://pubmed.ncbi.nlm.nih.gov/15522942/ https://pubmed.ncbi.nlm.nih.gov/27569118/ https://pubmed.ncbi.nlm.nih.gov/23408502/ https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.2019.33.1_supplement.819.10 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017674/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895342/ https://n.neurology.org/content/88/16_Supplement/P3.090 https://pubmed.ncbi.nlm.nih.gov/6859089/ https://www.ncbi.nlm.nih.gov/pubmed/10232622 https://pubmed.ncbi.nlm.nih.gov/21410865/ This list compiled over years of research by the user known as Pottenger's Human on youtube. 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