Comments by "Mark Pawelek" (@mark4asp) on "Dr. John Campbell"
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No. I would take the maximum allowed in UK, which is 4000 IU per day.
1000 ng = 1 µg = 40 IU
1000 µg = 1 mg
A safe dose of vitamin D leads to a blood level above 50 ng/mL in blood. Any level above 50 ng/mL and below 150 ng/mL of vitamin D is considered safe. Vitamin D exists is 3 forms. It is stored in fat cells. Vitamin D3, from fat, or sunlight, is converted to the active vitamin D form in the kidneys. Vitamin D3 is the normal form found in pills and capsules.
A recent study found that, after several months, of a dose of 20000 IU per day, people still had blood levels below 100 ng/mL of vitamin D. None of them developed Vitamin D toxicity symptoms. Everyone in UK should take at least 4000 IU/day. It's a good idea to take vitamin K2 with the vitamin D. Taking vitamin K2 with vitamin D3 helps to ensure the calcium transported by the vitamin D is absorbed by your bones where it's needed
Vitamin D toxicity? Only ever seen with truly massive vitamin D doses! "In the 1940s, vitamin D was thought to be effective for treating rheumatoid arthritis and massive doses of 200,000 to 300,000 IU/day were given. It was soon realized that these massive doses resulted in vitamin D intoxication, including hypercalcemia, hyperphosphatemia, nephrocalcinosis, kidney stones, and soft tissue calcifications."
Read: Holick, M. F. (2015). "Vitamin D Is Not as Toxic as Was Once Thought: A Historical and an Up-to-Date Perspective". Mayo Clinic Proceedings, 90(5), 561–564. doi:10.1016/j.mayocp.2015.03.015 https://www.mayoclinicproceedings.org/article/S0025-6196(15)00244-X/fulltext
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Untrue. Vitamin D3 builds up in your body. It is stored in fat cells. D3 is an inactive form of vitamin D. The active form, in your blood, is made from D3 in your kidneys. 10000 IU of vitamin D3 per day is safe. Ten times that is dangerous. Vitamin D toxicity is only ever seen with truly massive vitamin D doses!
"In the 1940s, vitamin D was thought to be effective for treating rheumatoid arthritis and massive doses of 200,000 to 300,000 IU/day were given. It was soon realized that these massive doses resulted in vitamin D intoxication, including hypercalcemia, hyperphosphatemia, nephrocalcinosis, kidney stones, and soft tissue calcifications."
- Holick, M. F. (2015). "Vitamin D Is Not as Toxic as Was Once Thought: A Historical and an Up-to-Date Perspective". Mayo Clinic Proceedings, 90(5), 561–564. doi:10.1016/j.mayocp.2015.03.015 https://www.mayoclinicproceedings.org/article/S0025-6196(15)00244-X/fulltext
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In UK, Psilocybin and MDMA are both classed as "class A drugs". The most highly restricted and, supposedly, the most dangerous. 'Psilocybin extract' since the Misuse of Drugs Act, MDA 1971. MDMA since 1977 when the MDA was amended. UK law says drugs are 'classified' as "dangerous drugs", or "otherwise harmful". One aspect of "otherwise harmful" is "socially harmful". None of these terms are ever explained in detail. The short legal description is all the explanation there is of why they're considered so dangerous! [ UK 'classified drugs' are like USA 'scheduled drugs' ]. In 2006 when the committee who classify drugs were asked to explain, to the Parliamentary select committee on science and tech why Psilocybin became a class A drug, they could not answer the question. Cost-benefit calculations were never behind these classifications. The law is all based on "expert opinion" (just like lockdowns were). When one member of this committee (who recommend the classifications), David Nutt, later published something approaching a cost-benefit analysis he, basically, sacked himself from his (unpaid) post.
WARNING: I've known two people who took LSD and/or Psilocybin "recreationally" and went (temporarily) 'mad'. They were hospitalised for 2 weeks each. Please don't treat magic mushrooms as toy.
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