Comments by "Dr. Ricco Lindner" (@Dr.RiccoMastermind) on "Scientists Just Created World's First Smart Insulin - Breakthrough Explained" video.

  1. Being a biochemist, I didn't quite understand why you need to engineer regulating add-ons to an artificial insulin molecule when the natural insulin molecule seems to do the job as well? Is it because the natural self-regulation mechanism is not designed to "hyperinsulinemia" since this would be prevented by the pancreas? What about a much longer half-life of this artificial and modified insulin to reduce the total amount of injected insulin then in longer intervalls? Else I really appreciate this progress and design evolution story!! 🙏😎
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  2. @ChuckvdL  this was my knowledge as well till now, but in the video he mentioned that both tail ends can bind (but maybe don't usually do) to each other, so insulin doesn't bind anymore. Yeah, giving always-on-insulin is very hard to dose correctly according to food intake 🙈 Amazing protein engineering in this project!
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  3. @Jay_Johnson  yeah, I was confused by the indicated idea, that insulin might naturally shut off itself in vivo. 🙏
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  4. @philipm3173  indeed, I was not aware of this fact. Thank you!
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