Comments by "Orionishi" (@orionishi6737) on "Mandated vaccine, the science" video.
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@foxwylde2510 sigh...not exactly....you are almost there.
Regardless, this history humbles vaccine scientists. They know that they hold people’s lives in their hands. As stated by Dr. Maurice Hilleman, perhaps the most prolific vaccine scientist in history, “I never breathe a sigh of relief until the first few million doses are out there,” (Personal communication, Paul Offit, 2004). For this reason, scientists and public health officials carefully analyze and continually monitor the data related to every vaccine before, during and after it becomes available.
Even with this history in mind, some reasonably wonder about the COVID-19 vaccines because they have not previously been approved for use in people. But here, too, we can be confident in what we know:
mRNA vaccine
Although COVID-19 mRNA vaccines are new, this type of vaccine has been studied in people before. mRNA vaccines against HIV, rabies, Zika and flu have been tested in phase 1 and phase 2 trials in people. The technology has also been used in clinical trials as a way to treat some cancers. Even though these products have not been licensed for use in people, these efforts provided important information about mRNA technology and its safety.
mRNA is made and used in protein production in all cells of our bodies. As such, cells have mechanisms in place to ensure that no protein is made in quantities greater than needed. One way this happens is that mRNA has a “poly(A) tail.” In the cytoplasm, this tail ensures mRNA decay. As the mRNA is used to make proteins in the cell, the length of the poly(A) tail decreases, until it is too short for the mRNA to continue being used as a protein blueprint. Once this happens, the mRNA breaks down and is removed as cellular debris. This process limits how long mRNA remains in the cytoplasm — and, therefore, how much protein is produced.
As such, poly(A) tails ensure that the cell breaks down the vaccine mRNA in a timely manner. Likewise, this understanding allows scientists to design vaccine-delivered mRNA in a way that ensures it does not stay in the cell longer than needed to generate immunity.
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This is just an ignorant lie. Not even close to true. The vaccines were almost done with phase 3 trials when we started to get them.
Regardless, this history humbles vaccine scientists. They know that they hold people’s lives in their hands. As stated by Dr. Maurice Hilleman, perhaps the most prolific vaccine scientist in history, “I never breathe a sigh of relief until the first few million doses are out there,” (Personal communication, Paul Offit, 2004). For this reason, scientists and public health officials carefully analyze and continually monitor the data related to every vaccine before, during and after it becomes available.
Even with this history in mind, some reasonably wonder about the COVID-19 vaccines because they have not previously been approved for use in people. But here, too, we can be confident in what we know:
mRNA vaccine
Although COVID-19 mRNA vaccines are new, this type of vaccine has been studied in people before. mRNA vaccines against HIV, rabies, Zika and flu have been tested in phase 1 and phase 2 trials in people. The technology has also been used in clinical trials as a way to treat some cancers. Even though these products have not been licensed for use in people, these efforts provided important information about mRNA technology and its safety.
mRNA is made and used in protein production in all cells of our bodies. As such, cells have mechanisms in place to ensure that no protein is made in quantities greater than needed. One way this happens is that mRNA has a “poly(A) tail.” In the cytoplasm, this tail ensures mRNA decay. As the mRNA is used to make proteins in the cell, the length of the poly(A) tail decreases, until it is too short for the mRNA to continue being used as a protein blueprint. Once this happens, the mRNA breaks down and is removed as cellular debris. This process limits how long mRNA remains in the cytoplasm — and, therefore, how much protein is produced.
As such, poly(A) tails ensure that the cell breaks down the vaccine mRNA in a timely manner. Likewise, this understanding allows scientists to design vaccine-delivered mRNA in a way that ensures it does not stay in the cell longer than needed to generate immunity.
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@bluecoffee8414 we used all the other vaccines before longterm trial phases were done too. They only have to make it through phase 3 trials to be deemed safe enough for the general use in the public.
The COVID-19 vaccines hadn't finished phase 3 trials when we began to distribute them but they had made it through phase 1 and 2 trials. Shortly after that release they completed phase 3 trials.
On top of that there had been a decade of use and testing on humans before 2020.
Regardless, this history humbles vaccine scientists. They know that they hold people’s lives in their hands. As stated by Dr. Maurice Hilleman, perhaps the most prolific vaccine scientist in history, “I never breathe a sigh of relief until the first few million doses are out there,” (Personal communication, Paul Offit, 2004). For this reason, scientists and public health officials carefully analyze and continually monitor the data related to every vaccine before, during and after it becomes available.
Even with this history in mind, some reasonably wonder about the COVID-19 vaccines because they have not previously been approved for use in people. But here, too, we can be confident in what we know:
mRNA vaccine
Although COVID-19 mRNA vaccines are new, this type of vaccine has been studied in people before. mRNA vaccines against HIV, rabies, Zika and flu have been tested in phase 1 and phase 2 trials in people. The technology has also been used in clinical trials as a way to treat some cancers. Even though these products have not been licensed for use in people, these efforts provided important information about mRNA technology and its safety.
mRNA is made and used in protein production in all cells of our bodies. As such, cells have mechanisms in place to ensure that no protein is made in quantities greater than needed. One way this happens is that mRNA has a “poly(A) tail.” In the cytoplasm, this tail ensures mRNA decay. As the mRNA is used to make proteins in the cell, the length of the poly(A) tail decreases, until it is too short for the mRNA to continue being used as a protein blueprint. Once this happens, the mRNA breaks down and is removed as cellular debris. This process limits how long mRNA remains in the cytoplasm — and, therefore, how much protein is produced.
As such, poly(A) tails ensure that the cell breaks down the vaccine mRNA in a timely manner. Likewise, this understanding allows scientists to design vaccine-delivered mRNA in a way that ensures it does not stay in the cell longer than needed to generate immunity.
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