Comments by "Laurence Fraser" (@laurencefraser) on "Why Don't Cities Use Hexagon Blocks?" video.
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@xenaretos two options. One is to just declare some long wiggly bits to be a single, slightly higher priority road (the city I live in already does this due to remoddling intersections based on the traffic patterns: the natural 'straight through' direciton has you on a different road while 'turning' keeps you on the same one, name and numbering wise).
The other is to just number the hexagons, start from their most-compass-aligned point (whichever direction that may be in your particular arrangement), and then number around the outside of it (and/or the inside, depending how it's set up). Or use letters, if they're the right size and divided up correctly (you could have 13 exterior and 13 interior, or 26 of each, or just 26 around the outside, etc.), Or you could cut up the interior in other ways and do other things with it, whatever.
Assuming just hexagons as the base with the interior chopped up in various ways, anyway.
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