Comments by "Theodore Shulman" (@ColonelFredPuntridge) on "Dr. John Campbell" channel.

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  29. The argument that we should test the Paxlovid on patients who have been immunized (either by vaccination or by infection and natural immune-response), is good. By all means, test it on them! BUT it's reasonable to assume, until large tests are complete, that Paxlovid will benefit immunized patients in the same way it benefits those who have not been immunized. I'll explain why: Paxlovid is a combination of two medications. One of the two is Ritonovir, which doesn't do much by itself, but is useful for prolonging the lifetime of other protease-inhibitors. You can think of Ritonovir as like the linemen on a football team whose purpose is blocking the other team, to protect the guy who has the ball from being tackled by them. The other drug in Paxlovid is Nirmatrelvir, which is like the guy who has the ball. It inhibits the virus' protease enzymes which are essential to make the proteins it needs in order to control the host cell. Without those protease enzymes, the virus can't do its bad viral thing to you. The point here is, both these effects - the Nirmatrelvir inhibiting the virus' essential protease enzymes, plus the Ritonovir preventing the host from removing the Nirmatrelvir - both these effects are completely separate from antibodies and what antibodies do. In fact, as far as anyone knows, they are separate from the entire immune system. They inhibit the viral protease enzymes in the presence of antibodies, and they inhibit the viral protease enzymes in the absence of antibodies. Given what we know about how well they work for patients who have not been immunized, and given that their mechanisms of action have nothing to do with immunity or antibodies, it's reasonable to predict that they will also work well to protect patients who HAVE been immunized. This is not proof - of course, only big tests on previously-immunized patients would prove the benefit in those patients. But it IS a good reason to provide the Paxlovid unless and until large studies or surveys prove that it DOESN'T help those patients. The fact that Paxlovid has such great results on patients who have not been immunized, plus the fact that the mechanism of action is independent of antibodies, shifts the burden of proof to the skeptics, at least largely.
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  36. First of all, no, it's still an hypothesis, not "a bit more". Secondly, Dr. Campbell is speaking as if it went without saying that the only possible reason to redact information about the virus were something embarrassing in it. But there might well be something dangerous in it. Everyone is quite sure that this virus SARS-CoV-2 was not purposely engineered or released as a bio-weapon, but the next one, or the one after that, could well be. It's getting easier and easier to engineer new variants (if anyone wanted to do that) and there could be some information which the Brits don't want to release, for very good reason. The fact that the virus stores its genetic information in the form of viral RNA rather than DNA, and the unusually large size of the RNA (30 kilobases), were obstacles for a while, but we seem to have overcome them (see the work of Volker Thiel in Switzerland) and it is getting uncomfortably easy to mess with the viral genome. We can make, for instance, variants of the virus which cause infected cells to glow in the dark (by cloning in a gene for a jellyfish protein which glows, called Green Fluorescent Protein, "GFP"). That means we can likely also make variants which would do other, less harmless things. If we release all the information, quite soon some apocalypse-minded guy with a bit of knowledge and too much of money (think Osama bin Laden if he had taken a PhD in virology and worked in biotech for a few years) could produce something very nasty indeed (imagine a variant virus which made 20% of patients go permanently blind). So don't be so quick that every redaction is for the sake of avoiding embarrassment! It could be something to protect you. Go review Isaac Asimov's short story "The Dead Past". Money quote: "Nobody knew anything," said Araman bitterly, "but you all just took it for granted that the government was stupidly bureaucratic, vicious, tyrannical, given to suppressing research for the hell of it. It never occurred to any of you that we were trying to protect mankind as best we could."
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  117.  @Mark_Meisho_Thompson  I had an EKG done at an urgent care center, and the results appeared normal. I didn't discuss them with the technician who took the data, but the results sent to my primary care physician showed normal ekg patterns. Then I got the jab, and two weeks later, the cardiologist's office reported to the primary care doctor that the first results of the EKG - the normal-appearing result - had been reported as result of a clerical error and that I had actually had atrial fibrillation at the time. A friend of mine had a similar event, but she missed her appointment for the jab and did not get one, and it turned out in her case that her cardiologist had made an error too, but his error was that he had erroneously thought his office had made an error and that her apparently-normal result was wrong. But after she missed her appointment and did not get the jab, the cardiologist sent a second notice to her primary care doctor, saying that his report of an error was itself erroneous (caused by a clerical worker who was addicted to prescription medications and had made a number of similar wrong diagnoses of clerical errors, which were very embarrassing for her employer the cardiologist) and that her original result - normal rhythm - was in fact correct. So I, who got the jab, had atrial fibrillation before getting it, and she who had only scheduled the jab but not gotten it, had had a normal rhythm before failing (and later declining) to get it. So we think now that my getting the jab was what caused me, retroactively, to have atrial fibrillation before I got it, and that if I had not gotten the jab, then I would not have had atrial fibrillation before not getting the jab. I know this seems unlikely - the idea that a vaccine could cause an adverse side-effect before the vaccine is administered, but this pandemic is so full of surprises that some suspension of disbelief seems to be warranted. (A good scientist must always be open to new possibilities which previously seemed impossible or at least very counterintuitive.) Also, similar cases have been reported in other parts of the world: Russia (Vologda) and one from Indonesia. There may also be additional cases which were never reported because the physicians involved simply could not accept the possibility of temporally retroactive side-effects. So my case may only be the tip of the iceberg.
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  124.  @bobbobertson6249  More to the point, if you got sick after one dose, then why in the world did the doctor - why in the world would any doctor - tell you to take a second dose??? Of anything??? Doctors know that although complications are rare, they do, sometimes, happen to some patients, and they will advise you not to take a second dose if you react badly to the first one. At very least they will tell you to try a different vaccine, which has a different formulation from the one that caused the bad reaction. The whole line "I suffered a bad reaction to the first dose and my doctor said it was my imagination and pressured me to take a second dose!" is almost always a lie being told by a knee-jerk-ideological anti-vaxxer who thinks that vaccines are contrary to his god's plan or some such loop-a-dupery. In real life, any doctor to whom you report having had a bad reaction to anything (to a vaccine or to anything else) will tell you to stop whatever the thing you reacted to was, unless it's absolutely necessary to keep you alive. No doctor says, for instance, that if you break out in a rash after taking vitamin D, or feel too keyed up to sleep when drinking coffee, or have a bad response to Viagra, then you have to take more vitamin D, or coffee, or Viagra. What possible benefit could there be for the doctor or for the patient in making you repeat a stimulus which you had reacted badly to??? Doctors want their patients to get well and stay well. That's what it means for a doctor to be doing his job well.
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  142.  @FJB8885  These are personal questions. But I'll tell you a few things: No, I'm not a physician; I didn't like med school. These days you hear a lot about doctors quitting; well, I quit trying to practice medicine after I finished my first clinical rotation. It's a challenging, honorable profession, but when you actually get on the wards and start trying to do it, it's way too much like being in the army; you have to be polite to everyone even when you want to punch them in the face. I am retired; when I worked, I was an antibody-chemist. I have immunized hundreds (literally) of animals, and bled them, and tested their blood for antibody-responses. I have designed methods for using antibodies for various purposes for many different scientists on many levels (including lowly start-up profs at minor schools. and big-shot winners of accolades such as the National Medal of Science, the and the Nobel prize, and everyone in between) and in many specialties, including plant biology, oncology, neurological embryology, environmental chemistry, and cardiology. (Antibodies are very versatile scientific tools.) I have validated vaccines against weapons pathogens for the Department of Defense. I don't teach medicine, but I have trained grad students and post-doctoral fellows and young professors to do antibody work, and also I had a side-hustle tutoring practice helping undergrads with pre-med sciences, for what was at the time considered a high-end fee. A few of my former pupils and trainees are successful scientists now, and some who are not scientists are, at least, scientifically-literate non-scientists. I am also a reasonably good science writer. I have successfully raised grant money from NIH (NIDA) with my writing, long ago. When I was still working, some of my co-workers consulted me from time to time for proofreading services and stylistic improvement. The trick to writing a good grant proposal is to make it sound technical and dry, but to tell a metaphorical story so the readers feel excited without quite knowing why. But all this was long ago. Now I spend my time trying to be an amateur classical vocalist (bass-baritone). And what do you do to make ends meet, and to occupy your spare time?
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  147.  @StevenCashel  Absolutely. A lot of these anti-vax fictional stories are easy to spot because they attribute implausible behavior to doctors. The idea of a doctor who suspects worms or some other illness which is known to be treatable with Ivermectin, relying on the patient self-diagnosing the illness instead of testing the patient's stool (or whatever) is just silly. It would be rank malpractice. The medical board would ask him, under oath, "if you thought the patient might have worms (or any parasite), why didn't you test for them?" And if he can't give a good answer, then his career will be in danger. It's not difficult to test for parasites. You just dissolve a small sample of the patient's solid waste (or dead skin or hair or blood or whatever shedding part the suspected parasite is supposed to be occupying) in some water or saline, and use an inexpensive dipstick, like testing a woman's urine for pregnancy. Parasitic organisms make particular proteins which the human host does not make (just as pregnant women, and only pregnant women, make human chorionic gonadotropin (with a couple of exceptions like patients with certain cancers)), so the antibody-based dipstick can detect them. The idea of a doctor relying on a patient's word to determine whether the patient had or did not have worms (or some other parasite) is not plausible. Doctors are not generally careless, stupid, or self-destructive. Those who are get weeded out. Exceptions tend to be few, far-between, and visible, like rogue professionals who murder their patients, or gross serial-malpractitioners.
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