Comments by "Theodore Shulman" (@ColonelFredPuntridge) on "Dr. John Campbell"
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Brand new report in WSJ by Sarah Toy Friday March 18 2022 7AM
Ivermectin Didn’t Reduce Covid-19 Hospitalizations in Largest Trial to Date
Patients who got the antiparasitic drug didn’t fare better than those who received a placebo
MY SUMMARY: The study looked at patients who had COVID symptoms and a positive rapid-test, and a co-morbidity like diabetes, cardiovascular problems, lung disease, or high blood pressure. It divided the patients randomly into two groups and gave one Ivermectin and the other placebo. Then tracked admission rates, length of hospitalization, ventilator use, death rates, how fast they got better, and how fast they cleared the virus.
They did several analyses, including one which only included patients who said they followed the prescribed instructions carefully.
RESULT: No observable clinical benefit.
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The argument that we should test the Paxlovid on patients who have been immunized (either by vaccination or by infection and natural immune-response), is good. By all means, test it on them! BUT it's reasonable to assume, until large tests are complete, that Paxlovid will benefit immunized patients in the same way it benefits those who have not been immunized. I'll explain why:
Paxlovid is a combination of two medications. One of the two is Ritonovir, which doesn't do much by itself, but is useful for prolonging the lifetime of other protease-inhibitors. You can think of Ritonovir as like the linemen on a football team whose purpose is blocking the other team, to protect the guy who has the ball from being tackled by them. The other drug in Paxlovid is Nirmatrelvir, which is like the guy who has the ball. It inhibits the virus' protease enzymes which are essential to make the proteins it needs in order to control the host cell. Without those protease enzymes, the virus can't do its bad viral thing to you.
The point here is, both these effects - the Nirmatrelvir inhibiting the virus' essential protease enzymes, plus the Ritonovir preventing the host from removing the Nirmatrelvir - both these effects are completely separate from antibodies and what antibodies do. In fact, as far as anyone knows, they are separate from the entire immune system. They inhibit the viral protease enzymes in the presence of antibodies, and they inhibit the viral protease enzymes in the absence of antibodies. Given what we know about how well they work for patients who have not been immunized, and given that their mechanisms of action have nothing to do with immunity or antibodies, it's reasonable to predict that they will also work well to protect patients who HAVE been immunized.
This is not proof - of course, only big tests on previously-immunized patients would prove the benefit in those patients. But it IS a good reason to provide the Paxlovid unless and until large studies or surveys prove that it DOESN'T help those patients. The fact that Paxlovid has such great results on patients who have not been immunized, plus the fact that the mechanism of action is independent of antibodies, shifts the burden of proof to the skeptics, at least largely.
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The nearly-final question was why don't we waive the vaccination-mandates for people who already have natural immunity. One obvious problem is that testing for natural immunity is expensive! Even testing for antibody-titers would cost non-trivial amounts of money, and that is a very easy test to run. (Even I can run it.). Add in the cost of counting patients' memory B-cells, memory T-4s, and memory T-8s, and remember: you're not just counting total memory B, T4, and T8 cells; you have to count the number of memory B-cells which target the virus, and the number of memory T4 cells which target the virus, and the number of T8 cells which target the virus. (It's nice for a patient if he has a large number of memory T8 cells which "remember" that he once was exposed to, say, rabies, or Yersinia Pestis, but those cells will not also protect him from SARS-CoV-2, so you need to count only the cells which "remember" his previous exposure to SARS-CoV--2 which gave him the natural immunity.) Counting these cells is much more expensive than antibody-titering (which is why so many scientists rely on antibody-titering even though it doesn't always correlate with total immunity.)
I suppose we could have a policy of waiving vaccination requirements for people who have natural immunity to SARS-CoV-2, but, if you want to apply for the waiver, then you have to pony up the money for the tests. Which will certainly cost more - A LOT more - than just taking the damm vaccine!
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First of all, no, it's still an hypothesis, not "a bit more". Secondly, Dr. Campbell is speaking as if it went without saying that the only possible reason to redact information about the virus were something embarrassing in it. But there might well be something dangerous in it. Everyone is quite sure that this virus SARS-CoV-2 was not purposely engineered or released as a bio-weapon, but the next one, or the one after that, could well be. It's getting easier and easier to engineer new variants (if anyone wanted to do that) and there could be some information which the Brits don't want to release, for very good reason.
The fact that the virus stores its genetic information in the form of viral RNA rather than DNA, and the unusually large size of the RNA (30 kilobases), were obstacles for a while, but we seem to have overcome them (see the work of Volker Thiel in Switzerland) and it is getting uncomfortably easy to mess with the viral genome. We can make, for instance, variants of the virus which cause infected cells to glow in the dark (by cloning in a gene for a jellyfish protein which glows, called Green Fluorescent Protein, "GFP"). That means we can likely also make variants which would do other, less harmless things.
If we release all the information, quite soon some apocalypse-minded guy with a bit of knowledge and too much of money (think Osama bin Laden if he had taken a PhD in virology and worked in biotech for a few years) could produce something very nasty indeed (imagine a variant virus which made 20% of patients go permanently blind).
So don't be so quick that every redaction is for the sake of avoiding embarrassment! It could be something to protect you. Go review Isaac Asimov's short story "The Dead Past".
Money quote:
"Nobody knew anything," said Araman bitterly, "but you all just took it for granted that the government was stupidly bureaucratic, vicious, tyrannical, given to suppressing research for the hell of it. It never occurred to any of you that we were trying to protect mankind as best we could."
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From VAERS own web site:
Anyone, including Healthcare providers, vaccine manufacturers, and the public [including ideologically-driven loop-a-dupe anti-vax cultists and their for-profit enablers] can submit reports to the system [including fake reports, which don't usually get checked or exposed]. While very important in monitoring vaccine safety, VAERS reports alone cannot be used to determine if a vaccine caused or contributed to an adverse event or illness. Vaccine providers are encouraged to report any clinically significant health problem following vaccination to VAERS even if they are not sure if the vaccine was the cause. In some situations, reporting to VAERS is required of healthcare providers and vaccine manufacturers.
VAERS reports may contain information that is incomplete, inaccurate, coincidental, or unverifiable. Reports to VAERS can also be biased. As a result, there are limitations on how the data can be used scientifically. Data from VAERS reports should always be interpreted with these limitations in mind.
[…]
The number of reports alone cannot be interpreted as evidence of a causal association between a vaccine and an adverse event, or as evidence about the existence, severity, frequency, or rates of problems associated with vaccines.
Reports may include incomplete, inaccurate, coincidental and unverified information.
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My experiences with FDA (actually vicarious experiences - I didn't interact directly with them, but I worked alongside of some folks who did) was surprisingly good. Everyone at the company expected their (FDA's) people to be three-headed monsters but they turned out to be very smart, conscientious, energetic scientific bureaucrats, trying to do incredibly demanding jobs well.
FDA isn't perfect, but they manage to avoid most of the obvious possible blunders, which is the best one can expect from an agency like that, charged with preventing and correcting scientific errors in a very esoteric, rapidly-evolving field.
One other thing: it's a mistake to evaluate Dr. Fauci as an expert in HIV, COVID, FIKA, SARS, or vaccination, although he excels in all those areas. His central, nearly-unique expertise is in on how to deal with a much scarier, much more alarming pathogen: the terrifying scourge known as Pestis WeDon'tKnowWhatTheHellItIsYetOrWhatIt'sGonnaDoNext. Now that is a challenging specialty.
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It is a weapon. It was designed and unleashed in 2019 because at that time, the classical music world in Europe and USA and even South America had rediscovered Puccini’s last, unfinished opera Turandot. (If you have ever heard of an aria for tenor called ”Nessun dorma”, that’s from Turandot.) This opera is very offensive to Xi and the Chinese ruling party, because it depicts the Chinese people as brutal savages ruled by a sadistic tyrant. Opera houses all over the free world were planning, in 2019, to stage it in 2020. It's very challenging, for everyone - the soloists, the chorus, the orchestra, the costumers, the set-designers, everyone. La Scala, the Metropolitan, Lyric Opera of Chicago, Covent Garden, DeutscheOper Berlin, and even the little “petit-grand” opera companies like Regina Opera in Brooklyn and West Bay Opera in Palo Alto were going to take a crack at Turandot. The Chinese government released the virus in order to stop it.
A telling detail: they seem to have succeeded. Now that the pandemic is (hopefully!) fading, the opera companies are doing plenty of Puccini, but not Turandot! They’re doing La Bohème, and Il Trittico, and a few of the earlier ones, but not Turandot.
That's why they designed it to have such mild pathology, Dr Campbell. They weren't trying to kill a lot of people, just to make enough people sick enough to shut down the opera houses for a while so that the global classical music community could move on.
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@christopherrobinson7541 Yes, but remember, the benefit of Paxlovid is NOT that it stops the virus from entering the cell. I don't think it does stop that. What it stops is this: the virus mostly doesn't have separate genes for its proteins; it has one long stretch of genetic information (RNA) which codes for all the proteins. The virus enters the cell, releases the viral RNA, and the cell produces one big proto-protein - one long chain of amino acids, whose sequence includes all the viral proteins, strung together in one long chain, and then that chain gets cleaved, or chopped up by a protease enzyme, into the specific proteins the virus needs. The nirmatrelvir in the Paxlovid stops the "chopping up" process. This happens after, and independently from, the virus entering the cell.
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@colleenlazoruk2897 Of course, there are blood vessels in muscle! Everybody knows that.
But you see, I'm not asking for reasons why it might make sense for aspiration to be useful or beneficial.
I once knew a surgeon/scientist, whose job included evaluating proposals for innovation. He used to say: you can make all the arguments you like, but in the end, if you can't show, with statistically-large, double-blind, properly-controlled studies that your medication, regimen, device, procedure, protocol, or strategy actually does save lives (or bring measurable benefit to patients), then you're just jerking yourself off with your arguments about why it ought to work or might save lives or bring benefit to patients. The proof of the pudding is in the eating of it (as the fellow said).
So, once again: do you know of any ACTUAL STUDIES (double-blind, statistically large comparisons) which show that aspiration ACTUALLY DOES make patients safer than injection without aspiration?
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@kd4315
RE: "I find myself almost amused at your attempt to use the English language. "
What are you talking about? English is my native language. I grew up in New York City. (I can also get by in Russian, German, Polish, Italian, and French, and I have sung in Georgian, Latvian, Ukrainian, Church Slavonic, and Lezghin, although I can't really speak or write in those languages.)
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I've said it before and I'll say it again: the Chinese government unleashed the virus on us in order to prevent the opera houses in Europe and USA and South America from staging Puccini's last opera, Turandot (if you are familiar with the aria "Nessun dorma", that's from Turandot) because it is set in Peking ("Pekino") and depicts the Chinese people as brutal savages ruled by a sadistic tyrant. Turandot had become trendy again (the opera world is very faddish) and numerous opera houses, great (La Scala, the Met, Chicago Lyric Opera) and small (Regina Opera in Brooklyn) were getting ready to do it. The current government of China - Xi - couldn't stand for that.
Now that the pandemic has more or less resolved (not just temporarily, we hope) the companies are doing operas by Puccini, but, notably, not Turandot. They're doing La bohème and Il Trittico. So the Chinese strategy seems to have worked.
This is why the pathology of COVID is so harmless, relative to what it could have been. The Chinese government didn’t want to kill a lot of people, only to sicken us enough to shut down the opera houses and get the companies to choose a different repertoire.
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@edwardponder66
The Chinese government unleashed the virus on us in order to prevent the opera houses in Europe and USA and South America from staging Puccini's last opera, Turandot (if you are familiar with the aria "Nessun dorma", that's from Turandot) because it is set in Peking (Pekino) and depicts the Chinese people as brutal savages ruled by a sadistic tyrant. Turandot had become trendy again (the opera world is very faddish) and numerous opera houses, great (La Scala, the Met, Chicago Lyric Opera) and small (Regina Opera in Brooklyn) were getting ready to do it. The current government of China - Xi - couldn't stand for that.
Now that the pandemic has more or less resolved (not just temporarily, we hope) the companies are doing operas by Puccini, but, notably, not Turandot. They're doing La bohème and Il Trittico. So the Chinese strategy seems to have worked.
This is why the pathology of COVID is so harmless, relative to what it could have been. The Chinese government didn’t want to kill a lot of people, only to sicken us enough to shut down the opera houses and get the companies to choose a new repertoire.
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Don't you believe it! Dr. Campbell is a swamp-stooge like everybody else. If you ask him, he'll be the first to say so.
"A true revolutionary patriot cannot trust anyone or anything. Everything in this world - humanity, animals, plants, microbes, fungi, the entire pan-biome, the government, the government's enemies, the bankers and the communists, the Jews and the Clergy and the Freemasons and the Satanists and the atheists and the humanists, the professors and the drop-outs, the elite and the hoi-polloi, your doctors and your lawyers and your own family, all the angels and all the devils and all the demigods and djinni, and God Himself - are all your enemies, and all equally so."
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@Mark_Meisho_Thompson
I had an EKG done at an urgent care center, and the results appeared normal. I didn't discuss them with the technician who took the data, but the results sent to my primary care physician showed normal ekg patterns. Then I got the jab, and two weeks later, the cardiologist's office reported to the primary care doctor that the first results of the EKG - the normal-appearing result - had been reported as result of a clerical error and that I had actually had atrial fibrillation at the time. A friend of mine had a similar event, but she missed her appointment for the jab and did not get one, and it turned out in her case that her cardiologist had made an error too, but his error was that he had erroneously thought his office had made an error and that her apparently-normal result was wrong. But after she missed her appointment and did not get the jab, the cardiologist sent a second notice to her primary care doctor, saying that his report of an error was itself erroneous (caused by a clerical worker who was addicted to prescription medications and had made a number of similar wrong diagnoses of clerical errors, which were very embarrassing for her employer the cardiologist) and that her original result - normal rhythm - was in fact correct. So I, who got the jab, had atrial fibrillation before getting it, and she who had only scheduled the jab but not gotten it, had had a normal rhythm before failing (and later declining) to get it. So we think now that my getting the jab was what caused me, retroactively, to have atrial fibrillation before I got it, and that if I had not gotten the jab, then I would not have had atrial fibrillation before not getting the jab.
I know this seems unlikely - the idea that a vaccine could cause an adverse side-effect before the vaccine is administered, but this pandemic is so full of surprises that some suspension of disbelief seems to be warranted. (A good scientist must always be open to new possibilities which previously seemed impossible or at least very counterintuitive.) Also, similar cases have been reported in other parts of the world: Russia (Vologda) and one from Indonesia. There may also be additional cases which were never reported because the physicians involved simply could not accept the possibility of temporally retroactive side-effects. So my case may only be the tip of the iceberg.
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@bobbobertson6249 More to the point, if you got sick after one dose, then why in the world did the doctor - why in the world would any doctor - tell you to take a second dose??? Of anything??? Doctors know that although complications are rare, they do, sometimes, happen to some patients, and they will advise you not to take a second dose if you react badly to the first one. At very least they will tell you to try a different vaccine, which has a different formulation from the one that caused the bad reaction.
The whole line "I suffered a bad reaction to the first dose and my doctor said it was my imagination and pressured me to take a second dose!" is almost always a lie being told by a knee-jerk-ideological anti-vaxxer who thinks that vaccines are contrary to his god's plan or some such loop-a-dupery.
In real life, any doctor to whom you report having had a bad reaction to anything (to a vaccine or to anything else) will tell you to stop whatever the thing you reacted to was, unless it's absolutely necessary to keep you alive. No doctor says, for instance, that if you break out in a rash after taking vitamin D, or feel too keyed up to sleep when drinking coffee, or have a bad response to Viagra, then you have to take more vitamin D, or coffee, or Viagra. What possible benefit could there be for the doctor or for the patient in making you repeat a stimulus which you had reacted badly to??? Doctors want their patients to get well and stay well. That's what it means for a doctor to be doing his job well.
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OK. The definition of Serious Adverse Event seems to be: "An SAE was defined as an adverse event that results in any of the following conditions: death; life-threatening at the time of the event; inpatient hospitalization or prolongation of existing hospitalization; persistent or significant disability/incapacity; a congenital anomaly/birth defect; medically important event, based on medical judgment."
The thing is, all these events can result from getting the virus!
It's all very well to say "ooh, look, the swine-flu vaccine had far fewer adverse events, and they stopped vaccinating!" But how likely were the un-vaccinated patients to get swine-flu, and what was it likely to do to them? In other words, what were the likely damages done by not vaccinating??
Yes, we need a cost/benefit analysis, but until we get one there's no reason to assume that vaccinating is any worse than not vaccinating.
This is what happens when you try to produce, and deploy, a vaccine (or any other medical intervention) at "warp speed".
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RE: "On the last part of 2020, my brother got Covid, but had hardly any symptoms. When the injections came out he took the AZ one. Months later, he started having fainting spells. After some studies he was diagnosed with AF, Brudaga Syndrome and was implanted a Fibrilator."
Hmmm! How interesting. MY brother got the vaccine, and a few days later, his akin cleared up, he stopped having problems with erectile dysfunction, and he won $50,000,000.00 in the lottery.
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@FJB8885 These are personal questions. But I'll tell you a few things: No, I'm not a physician; I didn't like med school. These days you hear a lot about doctors quitting; well, I quit trying to practice medicine after I finished my first clinical rotation. It's a challenging, honorable profession, but when you actually get on the wards and start trying to do it, it's way too much like being in the army; you have to be polite to everyone even when you want to punch them in the face.
I am retired; when I worked, I was an antibody-chemist. I have immunized hundreds (literally) of animals, and bled them, and tested their blood for antibody-responses. I have designed methods for using antibodies for various purposes for many different scientists on many levels (including lowly start-up profs at minor schools. and big-shot winners of accolades such as the National Medal of Science, the and the Nobel prize, and everyone in between) and in many specialties, including plant biology, oncology, neurological embryology, environmental chemistry, and cardiology. (Antibodies are very versatile scientific tools.) I have validated vaccines against weapons pathogens for the Department of Defense.
I don't teach medicine, but I have trained grad students and post-doctoral fellows and young professors to do antibody work, and also I had a side-hustle tutoring practice helping undergrads with pre-med sciences, for what was at the time considered a high-end fee. A few of my former pupils and trainees are successful scientists now, and some who are not scientists are, at least, scientifically-literate non-scientists.
I am also a reasonably good science writer. I have successfully raised grant money from NIH (NIDA) with my writing, long ago. When I was still working, some of my co-workers consulted me from time to time for proofreading services and stylistic improvement. The trick to writing a good grant proposal is to make it sound technical and dry, but to tell a metaphorical story so the readers feel excited without quite knowing why. But all this was long ago. Now I spend my time trying to be an amateur classical vocalist (bass-baritone).
And what do you do to make ends meet, and to occupy your spare time?
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@StevenCashel Absolutely. A lot of these anti-vax fictional stories are easy to spot because they attribute implausible behavior to doctors.
The idea of a doctor who suspects worms or some other illness which is known to be treatable with Ivermectin, relying on the patient self-diagnosing the illness instead of testing the patient's stool (or whatever) is just silly. It would be rank malpractice. The medical board would ask him, under oath, "if you thought the patient might have worms (or any parasite), why didn't you test for them?" And if he can't give a good answer, then his career will be in danger. It's not difficult to test for parasites. You just dissolve a small sample of the patient's solid waste (or dead skin or hair or blood or whatever shedding part the suspected parasite is supposed to be occupying) in some water or saline, and use an inexpensive dipstick, like testing a woman's urine for pregnancy. Parasitic organisms make particular proteins which the human host does not make (just as pregnant women, and only pregnant women, make human chorionic gonadotropin (with a couple of exceptions like patients with certain cancers)), so the antibody-based dipstick can detect them.
The idea of a doctor relying on a patient's word to determine whether the patient had or did not have worms (or some other parasite) is not plausible. Doctors are not generally careless, stupid, or self-destructive. Those who are get weeded out. Exceptions tend to be few, far-between, and visible, like rogue professionals who murder their patients, or gross serial-malpractitioners.
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It's not, strictly speaking, a warfare agent, but it is a weapon. The timing of its release makes this obvious to anyone who follows the current trends in classical music. That sounds nutty, but bear with me.
The virus was unleashed in 2019 in order to prevent the opera houses in Europe and USA and South America from staging Puccini's last opera, Turandot (if you are familiar with the aria "Nessun dorma", that's from Turandot) because it is set in Peking ("Pekino") and depicts the Chinese people as brutal savages ruled by a sadistic tyrant. Turandot had become trendy again (the opera world is very faddish; all the opera companies watch all the other companies and try to do what they are doing) and numerous opera houses, great (La Scala, the Met, Chicago Lyric Opera) and small (Regina Opera in Brooklyn) were getting ready to do it. The current government of China - Xi - couldn't stand for that.
And look at how well their plan worked! Now that the pandemic has more or less resolved (not just temporarily, we hope) the companies are doing operas by Puccini, but, notably, not Turandot. They're doing La bohème and Il Trittico. So the Chinese strategy seems to have worked.
This is why the pathology of COVID is so harmless, relative to what it could have been. The Chinese government didn’t want to kill a lot of people, only to sicken us enough to shut down the opera houses and get the companies to choose a new repertoire.
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