Comments by "The Ride Never ends" (@therideneverends1697) on "VICE TV"
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haveing peeped his writeings while doing a paper on the history of amphetamine use, abuse, and the changes in the illicit market, it came across to me as a dude whos tweaker fixation has him charting novel routs for synthesis, because the whole thing is full of all sorts of wierd routs that are technically possible, but either impractical in even a legal FDA licensed facility due to easier options and immense expense, or outright dangerous.
Im no chemistry expert, My schooling is in History and Sociology, but in my skimming, not only where the D and L isomers routinely mixed up, one of the routs involved the use of a metalic catalyst in a reaction that, with my again minimal education in chemistry, stood out as something that would be violently exothermic, and was not listed as such, nor was any mention made in regards to the fact. If a clueless academic as myself could spot that one a mile away i shiver to think of all the other potentially catastrophic runaway reactions that could be hidden in that book that could very well kill the misguided individual trying their hand at unlicensed pharmacy
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No but also yes.
Meth is neurotoxic at certan blood levels, like many drugs its not inherently toxic at the correct dosage. which, according to the FDA, is 25MG for children, 40MG for adults daily. At those dosages excitotoxicity is not triggered. at to someone with no tollerence, those can absolutely get someone high.
the problem is when people chase the dragon so to speak, the dopaminergic system physically cannot make someone feel high after someones been exposed to peak levels for a prolonged perioid of time, the "High" comes from spikeing levels, once the body is too comfortable with high levels, no high can be had.
If someone knows that, cools it and goes to bed it can be used therapeutically and even recreationally without harm. Medically thats not to difficult as the dosage tends to be sub recreational, once people are trying to get high though the self control aspect can be very difficult to maintain
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@andrewandrews7427 Me personally? No
Tolerance with amphetamines is a tricky thing because you have two factors at play, sensitivity and tolerance.
Sensitivity is your body learning how to optimally utilize the substance, meaning for the first bit of using it the same dosage will actually work better upto a certain point before it levels off, for me it was about a month and a half. This is separate from tolerance and doesn't reset the same, if you take a week or two break it will take some time for your body to optimize but it will take more like a 2 or 3 days than a month, from what reading ive done this is life long, once your body learns how to most efficiently uptake the substance its like rideing a bike.
Tolerance on the other hand works like any other substance, that being said for consistent therapeutic effect its generally considered unnecessary to take tolerance breaks, once someone finds the dosage and redose cycle that works for them if they stick to it they can get very consistent results. The old school DRs will say you should take weekends off if possible, newer ones will often say thats unnecessary. For me in my experimentation ive done both, heres what i found
In 3 months of doing 15- 20 MG per dose 2 to 3 times a day i found therapeutic response (improved focus, improved mood, optimism, depression relief) stayed consistent throughout, many people take long acting tablets and get consistent results for years, i prefer instant tablets because they start working quicker and you get control over dosage and how often instead of take once in the morning and your on the ride 14 hours. Also sometimes depending on what you ate or if you ate ect you might need more or less, so i like the flexability. Also when i take 20MG i prefer to take 15 MG than 5 MG an hour later to avoid the headrush which is more recreational than useful. (save that for special occasions)
Takeing weekend breaks i found you do get for a lack of better words a noticeable "high" Monday and Tuesday but it doesn't seem to be any more useful therapeutically, once the headrush evens out the actual improvement in mood and focus is the same.
haveing done both in practice i just take them when i feel the need, I dont find tolerance has become a factor in therapeutic effectiveness at all
One thing i cannot emphasize enough is just how non addictive they are at therapeutic dosages, I take them when my ADHD symptoms interfere with quality of life or if my mood is unmanageably bad, and occasionally to do art stuff, at no point in a year or so of having them on hand have i ever experienced any withdrawals or cravings when not taking them.
For depression i think they are incredibly underutilized to the point of borderline malpractice, SSRIs can take months to work, if they work, in the process of finding a SSRI someone responds to and the correct dosage it can take a year or more on average and even then comes with the borderline guarantee of sexual side effects. Stimulants provide relief in half an hour and in my experience can improve your baseline mood.
If you have felt nothing but horrible for years on end just the experience of feeling good and knowing that it is possible to feel ok can really change your perspective twords the better.
So theres my speech, call me an amphetamine evangelical if you will but they can absolutely be life saving medications that are critically under utilized due to stigma
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Thing is amphetamines do make you smarter, 3-5 IQ points on average, the problem is people get hooked on the headrush aspect of it kicking in.
instead of appreciating the longer lasting effects on improved memory, cognition, self awareness and coordination, they compulsively use it in increasingly irresponsible ways (Snorting, smokeing, IV) to obtain that rush.
Second problem is methamphetamine is frankly just too strong for most peoples needs, its reserved medically for people who have an unusually high tolerance to amphetamine or who get side effects that cant be tollerated, for the vast vast majority of people meth is just not needed, they can get all the good effects from other amphetamines, without the wierd compulsive tweaker behavior. By useing some other amphetamine compound thats realistically probably quite easy to get from a DR.
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@DarkAttack14 Yeah i think the problem with stimulants is its a confident flow state in pill or powder form
In moderation it can really help you work through personal issues, finish a project, spark creativity or break out of your shell socially, if your being mindful of that it can be a wonderful experience.
but you have to keep in mind,
"i am on a drug, this drug will make me, confident, sharp, and inevitably i will overestimate my ability's, but everything i can do or experience while on it i can do while off it, its for learning how and having an experience" If your being grounded and pokeing fun at yourself its fine. If that parts not explained to you prior it can get dark fast.
thinking you can solve your lifes or the worlds problems in a few seemingly obvious steps then suddenly realizeing you cant when it wears off can be brutal, and i think when people take amphetamines at face value without keeping the nature of the drug in mind, thats where the addictive cycle can easilly start.
Getting wired is a here and there experience to be had on special occasions or to overcome roadblocks in life. Otherwise chaseing that feeling daily is a fools errend
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