Comments by "Allison James" (@allisonjames2923) on "Institute of Human Anatomy"
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Just an FYI from a practical on road perspective (I’ve been a Paramedic for 22 yrs & am a Critical Care Paramedic). Naloxone in the doses we use, doesn’t usually precipitate full withdrawal syndrome immediately. It certainly temporarily reverses the respiratory & sedative inhibitory effects of opiates, as well as the pleasurable effects, but it doesn’t usually cause the immediate onset of full withdrawal symptoms (severe anxiety, shaking, tears, runny nose, nausea, vomiting, pupil dilation with possible light sensitivity, insomnia, hyperactivity, exaggerated reflex responses, fast breathing, fast heart rate, sweating, high blood pressure, high body temp & yawning). However, in some cases it can cause seizures & acute pulmonary oedema. And if people’s blood & brains have been starved of oxygen for a prolonged period, and this is not corrected prior to giving them Narcan, by ventilating them (preferably with 100% oxygen), then they will wake up angry & swinging in a confused fight or flight response. Admittedly, in my region in Australia, we don’t have to reverse OD’s anywhere near as frequently as most American Paramedics seem to do, nor as frequently as in our biggest cities like Sydney. But I’ve never yet seen acute withdrawal symptoms present immediately, nor in the up to an hour I’ve been with patients post opiate OD reversal. Nor have I ever had patients seize or develop APO. Not saying it doesn’t happen, but that it’s not a guaranteed, nor extremely frequent event. We do have a practice of reversing hypoxia prior to administering Narcan though, so don’t know if this has any effect. I know that many agencies in areas with high overdose rates just administer Narcan immediately without ventilating them first. So the cells of the body may be hypoxic or have high metabolic waste from anaerobic metabolism which may contribute to the onset of withdrawal type symptoms. Or it may be dose dependent. Will have to do more research.
Also, If you go to hospital immediately after a Naloxone reversed overdose, or you have any symptoms from withdrawal of opiates (eg by going cold turkey), many of the symptoms can be managed by medication to make it a far less horrific experience. You don’t have to do it alone & you don’t have to do it the hard way. And, if you have taken a long-lasting opiate that lasts for longer in the body than the Narcan, you can renarcotise & overdose again. So if you give someone Narcan, don’t just assume that’s it & they’re fine. Keep an eye on them for hours. One more note - Narcan only works on opiates. It does not reverse the effects of other sedatives or tranquillisers. The latest extremely dangerous Fentanyl / Xylazine combo that is causing huge numbers of OD’s can only be partially reversed by Narcan. That’s one reason it’s an extremely dangerous drug, not to mention the necrosis (tissue death) & infection it causes which is causing people to lose limbs.
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Just an FYI from a practical on road perspective (I’ve been a Paramedic for 22 yrs & am a Critical Care Paramedic). Naloxone in the doses we use, doesn’t usually precipitate full withdrawal syndrome immediately. It certainly temporarily reverses the respiratory & sedative inhibitory effects of opiates, as well as the pleasurable effects, but it doesn’t usually cause the immediate onset of full withdrawal symptoms (severe anxiety, shaking, tears, runny nose, nausea, vomiting, pupil dilation with possible light sensitivity, insomnia, hyperactivity, exaggerated reflex responses, fast breathing, fast heart rate, sweating, high blood pressure, high body temp & yawning). However, in some cases it can cause seizures & acute pulmonary oedema. And if people’s blood & brains have been starved of oxygen for a prolonged period, and this is not corrected prior to giving them Narcan, by ventilating them (preferably with 100% oxygen), then they will wake up angry & swinging in a confused fight or flight response. Admittedly, in my region in Australia, we don’t have to reverse OD’s anywhere near as frequently as most American Paramedics seem to do, nor as frequently as in our biggest cities like Sydney. But I’ve never yet seen acute withdrawal symptoms present immediately, nor in the up to an hour I’ve been with patients post opiate OD reversal. Nor have I ever had patients seize or develop APO. Not saying it doesn’t happen, but that it’s not a guaranteed, nor extremely frequent event. We do have a practice of reversing hypoxia prior to administering Narcan though, so don’t know if this has any effect. I know that many agencies in areas with high overdose rates just administer Narcan immediately without ventilating them first. So the cells of the body may be hypoxic or have high metabolic waste from anaerobic metabolism which may contribute to the onset of withdrawal type symptoms. Or it may be dose dependent. Will have to do more research.
Also, If you go to hospital immediately after a Naloxone reversed overdose, or you have any symptoms from withdrawal of opiates (eg by going cold turkey), many of the symptoms can be managed by medication to make it a far less horrific experience. You don’t have to do it alone & you don’t have to do it the hard way. And, if you have taken a long-lasting opiate that lasts for longer in the body than the Narcan, you can renarcotise & overdose again. So if you give someone Narcan, don’t just assume that’s it & they’re fine. Keep an eye on them for hours. One more note - Narcan only works on opiates. It does not reverse the effects of other sedatives or tranquillisers. The latest extremely dangerous Fentanyl / Xylazine combo that is causing huge numbers of OD’s can only be partially reversed by Narcan. That’s one reason it’s an extremely dangerous drug, not to mention the necrosis (tissue death) & infection it causes which is causing people to lose limbs.
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