Comments by "mcozy333" (@mcozy333) on "JRE Clips" channel.

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  160. cannabis is a preventative medication ... the exact and complete opposite of pharma that only treats diseases that are already set in place . some doctors actually care and will direct people to treat themselves with their environment to lead into less disease ... they are specialists to diet mostly, not really doctors however. with biochemistry I can only find benefits in cannabis metabolism in our cells ... no proof of harm exists save for NIDA only looking at cannabis smoke the last 50 years or so ... America has been paying Israel 150k a year since 1965 to research it !!! they found the THC structure and are leading the Cannabinoid sciences because of all that funding ... a few years ago they wanted over a million $$$ but US refused . not to mention the 40 or more cannabinoid THC replica synthetic lab made drugs on the market ... pharma is salivating over cannabis plant and all of its viable lipid medical molecules ion there that can be remodeled in a lab to make them synthetically ... plus- Epidiolex ... that is the nail in the coffin as to whether cannabis is medical or not ( only Dumb people suill question that) ... Epidiolex is a cannabis plant tincture approved by the FDA and DEA ... GW pharma grows real life plants and then solvent extracts the CBD with grain alcohol then adds some THCV in there and flavoring to make a tincture ... passed all the "" qualifications """ ( paid $$$ to get it through) while real plant still contains no medial value schedule one drug go to jail if touching it eTC...........................
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  161.  @valentinogeorgievski  Yes , I am very aware of that and one of the reasons you see me on here posting about how medical the cannabis plant is and it cannot in any way harm us like a single compound pharma drug with those massive side effects acting like a poison in our bodies instead of supporting our cellular homeostasis ... phytocannabinoids support cellular homeostasis via bio-mimicry of the endocannabinoids ... phytocannabinoids are non selective metabolize ... that is KEY to how they cannot harm ... the plant cannabinoiods will only metabolize " non selectively " into cellular pathways in our cells that are already there to metabolize endocannabinods and that metabolism is based on need in the cell to make those types of lipid signals for cellular homeostasis. Marinol is perfect example ... people become paranoid and uncomfortable while using it compared to whole cannabis plant. Plus , we can tailor our response to cannabis metabolism via different delivery methods like Juicing raw plant compared to smoking it ... not at all like pharma with their one drug / one molecule single compound drug only approach . and the therapeutic index for cannabis is 50,000 to 1 ... it is capable of maintaining therapeutic value without the side effects or outright effects being toxic and poisonous to us as the metabolism supports the cells homeostasis response ... there are even set cannabinoid pathways in place to finalize the lipid signaling and eliminate the waste products into waste sequences . the cannabinoid type two receptors really handle a lot of that via recycling and Autophogy . I could type for days about it and still not show 1% of all there is tyo know about it while everyone seems in such fear and confusion ... I'm terribly sorry that people feel such a way and that interests have led such peole into that mind space ... tis why I only present actual provable findings with biochemistry , to stop the lies and uncertainty about the pl;ant and man
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  175.  @super_sketchy_time7993  Well, I an present my findings, there are so many research articles of endocannabinoid system and its function etc... as to cannabis plant' impact on the system the actives in there ( phytocannabinoids) are non selective lipid metabolites that bio-mimic endocananbinoids . this gets very complex very quickly .. Tetrahydrocannabinol ( THC) bio-mimics N archidonoylethanolamine ( Anandamide/ AEA) ... Cannabidiol ( CBD) bio-mimics 2 arachidonoylglycerol ( 2 AG) .. phytocannabinoids/ endocannabinoids keep in mind that the plant cannabinoids are lipid /terpenes ( C-21 terpenophenolics/ meroterpinoids) which means lipids with terpene back bone. that determines how we metabolize them ... phytocannabinoids as already structured cannabinoids are free flow/ free form cannabinoids ... we make endocannabinoids via cleaving phospholipids from the cell bi-layer that are there from an accumulation of essential fatty acids ( omega three/ omega six) consumed regularly in diets . people who lack those suffer from Severe endocannabinoid deficiencies ... look on store shelves, it is loaded with nothing but omega six which when consumed in such amounts leads to over oxidation in our bodies ./ cells etc... omega three is anti oxidants and reduces inflammation and fixes deficiencies in the cells ... phytocannabinoids take the omega three pathways in the cells and are anti oxidant compounds and help to restore the cellular pathways that are otherwise being deficient in there signaling based on to much omega six/ nine etc.... short and sweet, start eating omega three as much as possible from good sources such as small fish with less mercury in them etc.... you can find it in pl;ant algae too such as chlorella and spirulina but that form is not as digestible as small fish that eat the algae and that then have omega three in them from that digested form.
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  318.  @TheodoraKimmelHello  our endocannabinoid system transports and degrades lipids into biochemicals ... a cannabinoid is C-21/ C-24 ( Carbon) ... that is the shape /structure while the molecular weight is around 314 G/mol to 347 G/mol ..... we accumulate essential fatty acids ( EFAs) from the diets ( omega three/ omega six/ nine ) ... Why? we can only make C-9 in the cell ... after reaching C-9, cells then sequester phospholipids ( EFAs) from the bi-layer to form a full C-21/C-24 endocannabinoid... endocananbinoid is a biochemical compound that makes signaling receptors possible in the cell ... so the cell uses fatty acid binding proteins and Epoxides to Crystalize a cannabinoid receptors channel for the biochemical to express into ( confirmation of change) . ther are Thousands or articles, research papers on this and the research is just starting you can look into this without ever using cannabis in the wording or cannabinoids etc... look up specialized pro resolving lipid mediators ... ( Resolvins) . they are cannabinoids with out stating directly of the label as such . as to ( ECS) endocannanbinoid system and how cannabis effects that system ... there are numerous molecules and whatnot in the cannabis plant that are metabolically active ... phytocannabinoids bio mimic endocannabinoids ... phytocannabinoids are non selective metabolites in the ECS ... that means safe and cannot in any way select for a biochemical pathway but will go where cells need them . ECS consists of 70 trillion cells , all metabolically active tissue cells use cannabinoid siognaling to maintain them . predicted that each of those cells signal 15 thousand cannabinoids per second per cell ... so add up 70 till + 15k a second per and you have an idea of all that activity.... ther is so much more I could post here ( days I could go on)........ no time however to do that
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  404. here are cannabimimetics- they are cannabis like compounds found in spices and stuff, Also omega three... info here- https://www.sativaisticated.com/wp-content/uploads/2018/01/Cannabimimetic-phytochemicals-in-the-diet-%E2%80%93an-evolutionary-link-to-food-selection-andmetabolic-stress-adaptation-Gertsch-Medical-Cannabis-Medical-Research-for-the-Endocannabinoid-System-ECS.pdf http://themodern.farm/studies/Omega-3%20Deficiancy%20Abolish%20Endocannabinoid%20Function.pdf so, it works like this= omega fatty acids ( EFAs) from your diet become signalling molecules in your endoannabinoid system ECS. EFAs become HUFAs / PUFAs , high functioning fatty acids- poly unsaturated fatty acids. the enzymes of the cells form the cannabinoid molecules that get metabolized into the cannabinoid receptors of the cell. Certain spices ( terpenes) act as enzymes/catalysts and or metabolites when you ingest them... terpene spices become terpinoids in the ECS . terpinoids drive metabolism of cannabinoids by activating certain enzymes on the cells interior allowing intracellular penetration of those cannabinoids and subsequent metabolism. volatility of the sesquiterpenes allows them to disperse across the lateral plain of the lipid bi-layer diffusing selectively via catabolism into the cell cavities that act as membrane leaflets accepting those volatile terpenes as secondary metabolites ingesting cannabis provides a form of molecule that directly effects the entire endocannabinoid system but other cannabimimetics will provide some metabolism there too and cause similar effects... whole black peppercorns can be chewed on for the effects if you want to experiment black peppercorns reduce anxiety https://duckduckgo.com/?q=black+peppercorns+reduce+anxiety&t=ffcm&atb=v62-6__&ia=web it is the beta caryophyllene in peppercorns that act as a cannabinoid ... beta caryophyllene is a dietary cannabinoid https://duckduckgo.com/?q=beta+caryophyllene+is+a+dietary+cannabinoid&t=ffcm&atb=v62-6__&ia=web
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  479.  @FionaThorningArt  the biologically active ( Available) compound molecules from the plant are lipids / Terpenes ... C-21/ C-22 ... in our bodies the only purpose fro those type structures = Neuroprotection .... That Is It period ... As stated , Research of endocananbinoid system and what not leads me to type this in your speak up section . Here I am presenting 100% proof via biochemistry and an honestly asking you to do the same and proof at least one thing you are saying with biochemistry otherwise it is a bunch of people just saying a thing and bouncing those thoughts off everyone with nothing but opinion. this is what I have to present = Tetrahydrocannabinolic acid = C22H30O4 358.478 g·mol ... a non selective metabolite @ cb1 and cb2 N arachidonoylethanolamine ( Anandamide /AEA) = C22H37NO2 347.53 g/mol ..... a dual selective agonist metabolite @ cb1 and cb2 and there is more ! cannabimimetics ... lots of cannabis type compounds we come into contact with diet on the regular ... whole peppercorn is one of the main cannabimimetics because there is beta caryophyllene in peppercorns . I could go on this research is so encompassing and you seem very smart and intelligent .... take some time to look into the biochemistry ... Why not start with GOV/ NIH health patents on those compounds ?? cannabinoids as anti oxidants and neuroprotectants #6630507 there are 500 patents and growing .... mostly on FABPs and Epoxides , but many are for the cannabinoids themselves .. and this - Specialized pro resolving lipid mediators --- for people unwilling to look further into C-21 Terpenopheonolics from the cannabis plant for whatever reason they can choose to look into that action potential via the research of Resolvins ... that is what cannabnoids are basically . Anyway , just so you know and I feel I have to say this = when someone is High from cannabis ingestion they are not Crazy they are High ... the High is driving the action potential of the Amine of Ethanol ( arachidonoylethanolamine ) via inhibiting intracellular ions via Voltage gated / ligand gated cannainoid type b1 expression and cannabinoid type 2 receptors ... a cannabis high is a increase of intracellular ions .
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  817.  @bretdodger9869  all chordate life has an endocannabinoid system ... one of the main reasons that cannabis helps us is because our diets of to much pro inflammatory omega six leads us to have Severe endocannabinoid deficiencies as there is hardly any anti inflammatory omega three in our common food stuffs . phytocannabinoids metabolize as anti oxidant that is similar to omega three as the same cannabinoid receptor pathways are being metabolized into when ingesting plant cannabinoids . and you are 100% correct that the more metabolic agents in a formula or oil; etc.... makes it way better meds ... people ingesting THC Marinol will not ever have the same effect as whole spectrum full extract cannabis oil . and as to extreme cases, sure- but the Same exact pathways in our cells ( cb receptors ) are being activated/ down regulated when we ingest cannabis irregardless our state of health at the time ... for a perfectly healthy individual cannabis can help to prevent the very diseases that [people later treat for woth the plant , known aas preventative medication .. cannabis is also an adaptogenic herb ( Adaptogen) helping us to adapt to changes and maintaining cellular homeostasis and warding off viruses and infection ETC..... smoking the plant is probably the worst administration method as it destroys so much of the actives and makes it really dirty with soot ash and smolder ... so many better and viable ingestion methods ... were our Gov to get the heck out of the way we'd just grow as much as we need to make smoothies and Raw cannabis juice in a juicer ... as people still need sneak to toke that is the common norm trying not to get caught etc... all while we coul;d be growing forests of the stuff to treat people
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  947.  @rustyshackleferd7200  ok, I'll try and explain myself better ... did any of those Harms you mention come about in research of endocananbinoid system or other "" tests"" that do not mention endocananbinoid system or its function ETC....? this - NIDA research the last 45 years has been only approved " marijuana" research ... you think there was bias there or what ? I mean there are over 25 cannabinoid drugs on market !!!!! over 500 medical patents for cannabinoids and their derivatives like fatty acid binding proteins and Epoxides ( mostly all found with endocananbinoid research ) . Marinol / dronabinol / Cesamet / Syndros / Nabilone / and many more Epidiolex ! a cannabis tincture approved by FDA , DEA took it completely off scheduling here is the ECS explained ... ECS is part of all metabolically active tissue in man . ECS is the buffer to fats we eat as ECS relies on essential fatty acids to even make a signaling cananbinoid . we can make up to C-11 and then need to pull from the phospholipid bi-layer more EFAS to complete the cannabinoid signal ( C-21 / C-22) this is why ECS is a buffer ... ECS transports all lipids we consume into the cells for later sequestering of them to form intracellular communication with the extracellular space ( the matrix) ..... ECS is the only neurotransmitters to form signaling in retrograde ( post to pre) .... with all that here is the actual action ... 70 trillions cells in man each signaling 15,000 biochemicals a second per cell is eCS in action ... Each cannabinoid touches interior of cell 7 times before finalizing ( 7 trans membrane super family of receptors) the signal ... we create endocananbinoids on demand .... they are not stored but the EFAs are store4 to make them when needed . phytocannabinoids in free flow circulation ( if man ingests cannabis plant ) non selectively metabolize into cannabinoid receptors located on 70 trillion cells . all endocannabinoids are selective and exogenous cannabinoids are non selective ( Safe) ... Therapeutic index for phytocannabinoids is 50,000 to 1 , they are that safe. a few links - importance of PUFAS/HUFAS for brains https://duckduckgo.com/?t=ffcm&q=importance+of+PUFAS%2FHUFAS+for+brains&atb=v165-1&ia=web role of essential fatty acids in the formation of endocananbinoids https://duckduckgo.com/?t=ffcm&q=role+of+essential+fatty+acids+in+the+formation+of+endocananbinoids&atb=v165-1&ia=web Anti-inflammatoryω-3 endocannabinoid epoxides https://www.pnas.org/content/pnas/114/30/E6034.full.pdf I've read hundreds of these over the years and this is totally random just for you type of post ... hop you enjoy it !~
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  1316. ​ @Infamous_B_C  added metabolism from the lipids in the cannabis plant are directed to neurons ( intracellular calcium increases) ... some people handle that extra lipophilic / terpenophenolic metabolism with to much thought and fear basically ... hence the paranoia ETC... some people could feel as though they are having a mental breakdown from that added metabolism and possibly the fact that they could go straight into an incarceration scenario @ any moment from ingesting ILLEGAL plant life. as to how cannabis helps anyone , ingesting it is a form of preventative medicine . the anti oxidant / neuroprotective properties are the preventatives ... the same exact diseases people use the cannabis plant to treat later while sick and dying can be prevented ( the plant metabolizes in the same biochemical pathways in a healthy person as a dead and dying person) . While being used as a preventative the cannabis dosages can be very micro as compared to treating already in place diseases that need more concentrated forms of larger dosages ETC ..... as to pills - Phamra has made thesds and more = Marinol / Dronabinol / cesamet/ Nabilone / Rimonbrant / Syndros ... All Cannabinoid drugs synthetically made to mimic THC or other phytocannabinoids we have identified in cannabis species of plant life.... and there are way more Fatty acid binding protein drugs that interact with the G protein coupled receptors like cannabinoids do . more intersting = keep an eye out for bio-synthetic cannabinoid drugs made from yeast and E-coli ... those biosynthetics will better match/mimic real living cannabis made cannabinoids way better than the way we synthetically make them now .. you can read this patent too that describes the properties with biochemistry- patent # 6630507- cannabinoids as anti oxidants and neuroprotectants . Wall uh text , Sorry man just ramblin
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