Comments by "mcozy333" (@mcozy333) on "Joe Rogan - Effects of High Potency Marijuana, CBD | JRE Pot Debate" video.

  1. my last alcohol experience involved cannabis vaporized next day to heal the hangover from the alcohol .. that was my last experiment with the stuff too
    6
  2. No not at all .. in fact metabolizing the plant activates areas in our bodies that are cancer preventative .. activation of the endocannabinoid system .. ECS is our cancer defense
    2
  3. here is an article talking about that - Taming THC - Russo
    2
  4.  @bretdodger9869  forgot to mention and this is huge ... phytocannabinoids are non selective metabolites ! Tis why I even post about this as the plant cannabinoids ( C-21 Terpenophenolic meroterpinoids) in no way can cause harm or ever force into our cell receptors that could take over the cell etc.... like some drugs made do so and can kill us directly .... Selectivity is KEY
    2
  5. metabolizing the plant accesses TRPV1 receptors ... the heat receptors
    2
  6.  @Mr_Yow  CBD accesses TRPV1 more so than THC as CBD seems to have more beta caryophyllene as the main sesquiterpene
    2
  7.  @Mr_Yow  wow yeah not sure on that one LOL.... but, having an orgasm is a lot of anadmaide being created and 2-AG ... the same ligands that phytocannabinoids from the cannabis plant bio-mimic as they xpress into mans biochemistry as signaling lipids https://duckduckgo.com/?t=ffcm&q=signaling+lipids&atb=v165-1&ia=web beta caryophyllene is a dietary cannabinoid https://pubmed.ncbi.nlm.nih.gov/18574142/ taken from this search = https://duckduckgo.com/?t=ffcm&q=beta+caryophyllene+is+a+dietary+cannabinoid&atb=v165-1&ia=web here is how = https://www.sativaisticated.com/wp-content/uploads/2018/01/Cannabimimetic-phytochemicals-in-the-diet-%E2%80%93an-evolutionary-link-to-food-selection-andmetabolic-stress-adaptation-Gertsch-Medical-Cannabis-Medical-Research-for-the-Endocannabinoid-System-ECS.pdf
    2
  8.  @Mr_Yow  glad to help out ... let me know if you have questions here or there = anywhere
    2
  9. you either have a lack of FAAH or to much FAAH ... check out = Endocannabinoid tone / entourage effects of cannabis https://duckduckgo.com/?t=ffcm&q=Endocannabinoid+tone&atb=v165-1&ia=web https://duckduckgo.com/?t=ffcm&q=entourage+effects+of+cannabis&atb=v165-1&ia=web
    2
  10.  @nonserviam751  Indeed , ( Teal'c voice) .... here is something that people who use cannabis as meds use to increase how well cannabis can express ( bio-availability) . before ingesting cannabis chew on one or two whole peppercorns ... what that does is fill up cb2 receptors as the beta caryophyllene ( BCP) in the peppercorn is a cb2 Selective agonist /reverse agonist ... Selectivity is KEY , all of the phytocannabinoids from cannabis ( THC/ CBD and 147 more) are non selective metabolites that are present in free flow circulation but will not trigger or engage a cannabinoid receptor unless a need in the cell is there to signal them ... try that peppercorn trick and see if it works for you ... article ( always leave proof right?) = beta caryophyllene is a dietary cannabinoid https://duckduckgo.com/?t=ffcm&q=beta+caryophyllene+is+a+dietary+cannabinoid&atb=v165-1&ia=web
    2
  11. we are blinded by truth !
    2
  12. ther is a guy who ingested the entir 50 Gram dose of RSO in one sitting and lived to tell about it ... he was ingesting for cancer . Dr Bob Melamede talks about it https://www.youtube.com/c/doctorbobcannabuzz/videos
    1
  13. how cannabis supports our endocananbinoid system is Amazing ! you can support ECS via lipid metabolism too ... eat more omega three , use whole peppercorns before your cannabis ingestion ETC... omega three becomes endocannabinoids in our cells, thios is how we make lipid signaling
    1
  14. cannabis is dosage dependent ... amounts matter ( literally solid matter)
    1
  15. to throw a wrench into it as well = babies / Kids and little tiny people are benefiting from cannabis oil treatments ( RSO / FECO -activated glandular resin oils/ phytocannabinoids ) ... not just benefiting but finding those whole plant oil treatments way better than pharma single compounds meds where the Doc let them go because nothing pharma had worked ... cannab sis last resort when proven to be a lot more capable to treat people than pharma formulations . most notable = inoperable brain cancers / spinal column issues ... phytocannabinoids whn ingested rebuild and heklp the person to maintain hoemostasis ... where teh metabolism occurs in the cells is in the endocannabinoid system ... feel free. look any of this up
    1
  16. cannabis LD50 - 50,000 to 1 Alcohol = 10 to 1
    1
  17. eat whole peppercorns afterwards
    1
  18. yeah , it takes energy to make seeds and such that could otherwise go to making more glandular resin ( phytocannabinoids) .. but even still , cannabis is dosage dependent ... if a type has way more more medical lipids in it less is needed ... if a type has low cannabinoid content more is needed
    1
  19.  @robinsss  THC is a relaxant . THC acts a a free flow cannabinoid ( essential lipid) that non selectively metabolizes into cannabinoid receptors. as to GMO weed we have not even mapped the Cannabis genome completely yet ... one of the great things about prohibition is that it has kept cannabis out of GMO labs so far ... once fed " legal" it is game on . all of the different types of cannabis you can find now are a result of selective breeding practices
    1
  20. including moderation ... how to moderate moderation itself ?
    1
  21. that is rare and we are actually finding that NEEM oil pesticide is amajor cause of CHS ... it is an organic pesticide to boot and considered safe ... Azadarachtin
    1
  22.  @tangie06_33  here we go . I have talked with growers ... CHS is supposedly supposed to show up after a person has consumesd cannabis plant a long time ...well, with Azadaratchin in there CHS symptoms are from first time users . plus I'll leave you with this = how many Rastafarians and old time hippies are sufferring CHS ???
    1
  23.  @tangie06_33  because it is considered organic and safe ... it is like this ... if a person were to dab a NEEM oil dab they would be severely sick . THC too can effect gastric mobility and add in neem oil ontop and expect instant CHS symptoms ... supposedly the azadaratchin is not on the plant after a while of being sprayed but teh pl;ant soaks the neem oil up and if the grower does not flush correctly ETC it is in there ...
    1
  24. LD50 for cannabis is 50,000 to 1 ... aspirin for comparison - 13/20 to 1
    1
  25. look up RSO/ FECO treatments ... up to 10,000 mg daily .... for a dying person more is certainly better
    1
  26.  @bretdodger9869  all chordate life has an endocannabinoid system ... one of the main reasons that cannabis helps us is because our diets of to much pro inflammatory omega six leads us to have Severe endocannabinoid deficiencies as there is hardly any anti inflammatory omega three in our common food stuffs . phytocannabinoids metabolize as anti oxidant that is similar to omega three as the same cannabinoid receptor pathways are being metabolized into when ingesting plant cannabinoids . and you are 100% correct that the more metabolic agents in a formula or oil; etc.... makes it way better meds ... people ingesting THC Marinol will not ever have the same effect as whole spectrum full extract cannabis oil . and as to extreme cases, sure- but the Same exact pathways in our cells ( cb receptors ) are being activated/ down regulated when we ingest cannabis irregardless our state of health at the time ... for a perfectly healthy individual cannabis can help to prevent the very diseases that [people later treat for woth the plant , known aas preventative medication .. cannabis is also an adaptogenic herb ( Adaptogen) helping us to adapt to changes and maintaining cellular homeostasis and warding off viruses and infection ETC..... smoking the plant is probably the worst administration method as it destroys so much of the actives and makes it really dirty with soot ash and smolder ... so many better and viable ingestion methods ... were our Gov to get the heck out of the way we'd just grow as much as we need to make smoothies and Raw cannabis juice in a juicer ... as people still need sneak to toke that is the common norm trying not to get caught etc... all while we coul;d be growing forests of the stuff to treat people
    1
  27.  @bretdodger9869  report out about the anti inflammatory properties ( two actually, ther is load of info if you are interested) anti inflammatory W-3 endocannabinoid Epoxides https://www.pnas.org/content/114/30/E6034 cannabinoids as anti oxidants and neuroproectants / NIH/ GOV patent #6630507
    1
  28.  @bretdodger9869  Thanks, let me know if you learn anything from that or need more questions answered or if have have answers ... Peace out - Bless
    1
  29. marijuana is an tactical assault word ... that is its only purpose ... cannabis is the plant ( cannabaceaee family ) . NIDA controls all " marijuana" research in America ... see what they did there ? make up the problem and then control it via """"""" science""""""""""
    1
  30. and cannabis plant is an essential fatty acyl for man
    1
  31. without pain involved the experience will be different . whta you will find too is how much Cannabimimetics effect the over all way that cannabis metaoblizes .. https://www.youtube.com/results?search_query=Cannabimimetics
    1
  32. not only that what are the compounds ... ? they are lipids / terpenes ... extremely healthy for man . we rely solely on lipid signaling to maintain every cell in our bodies . here is the cannabis plant parts list - 570 total constituents / 150 are phytocannabinoids . about 60 of those phytocannabinoids are primary ( like THC-a /CBD-a) while the rest are not primary metabolites of the plant . each one of those molecular structures will activate intracellular receptor on all of our cells known as cannabinoid receptors
    1
  33.  @Mr_Yow  hello Mr Yow ... just dropping another line here with a link ... check this one - https://themodern.farm/studies/Omega-3%20Deficiancy%20Abolish%20Endocannabinoid%20Function.pdf well, a few more while I'm here - https://www.intechopen.com/books/cannabinoids-in-health-and-disease/dietary-omega-6-omega-3-and-endocannabinoids-implications-for-brain-health-and-diseases and ECS slide show - a nice computer set up best serves this type on presentation https://www.phytecs.com/tour-the-ecs/cannabinoid-signaling-at-the-synapse/
    1
  34. there is nothing being depressed ... metabolism of the cannabis is lipid based like an essential fatty acid ... metabolizing cannabis enlivens the cells
    1
  35. not at all - endocannabinoid system is not even taught in medical schools yet = https://duckduckgo.com/?t=ffcm&q=endocannabinoid+system&atb=v165-1&ia=web
    1
  36. phytocannabinoids are an essential fatty acyl for man ... we can only make up to C-12 before needing lipids from a dietary source to complete the molecule up to C-22 ... Essential fatyy acids are used to make the rest as we need those lipid signals in the cells ... phytocannabinoids are - C-22 terpenophenolic meroterpinoids
    1
  37. lethal dose of the plant is 50,000 to one .. and that is a loose representation as a person cannot physically ingest enough to kill him at once ... maybe chocking to death trying to cram it all down at once would do him in but that is suffocation and could occur with any plant matter that is being eaten to quickly ... the individual could poke his eyes out with a stalk or stem if not careful however ... beware
    1
  38. that is all I've got ... looking at it for a biochemistry standpoint we see the lipids /terpenes in the plant protect our cellular lining and provide a form of signaling ( lipid signaling) in the cannabinoid pathways. the action is identifiable in the endocannabinoid system
    1
  39.  @uxoriousNO  there is not much comparison to alcohol ( a very minor one) ... the Amines ( n-arachidonoylethanolamine / AEA / anandamide) are precursors to ethanol ( CBD / Diol) so in a way there is a minor alcohol reaction while metabolizing the cured out forms of the phytocannabinoids ( decarboxylation) . however in terms of the safety profile ... cannabis LD50 is 50,000 to 1 . alcohol LD50 is 10 to 1 ... cannabis is 50 thousand times safer and proved since the CDC measured all this in the 80's and developed Marinol
    1
  40.  @uxoriousNO  when we concentrate the plant into the constituents molecules ( phytocannabinoids) we are actually making a medicine ... FECO ( full extract cannabis oil) ... @ levels of treatments more are needed than rec use ... that says a whole damn lot right there as to how safe it is ... the more concentrated forms are medical , less of them are less medical ETC....
    1
  41.  @uxoriousNO  in many ways less is better . ingesting cannabis can causes a bi-phasic effect where the help or health part of it reverses . all of the pathways in relation to metabolizing the cannabinoids are backwards leaning pathways (retrograde) that down regulate via post to pre . here is a great slide show example of that action - Phytec tour the ECS http://www.phytecs.com/tour-the-ecs/cannabinoid-signaling-at-the-synapse/
    1
  42. people who say that are just guessing
    1
  43. same here, night sweats , issues with liver ... cannabis brought my waistline down a few inches and has held steady since irregardless how I eat . Iwas a tad over weight ... I found cannabis and smoked it a while then moved onto other more beneficial ways to ingest it like dry herb vapor and eating the plant
    1
  44.  @steveeparsonsjr7929  when you trace lineage most CBD varietals are from Sativa lineage ... there are now CBD kush types available. Apical Greens
    1
  45. hydro is hydrophonic not hydrogenated ..... grown in a water base solution ... hydrogenation is changing how fats solidify
    1
  46. so far teh only viable lipid research shows adding lipophilic / terpenophenolic mass ( C-21 / C-22) into a persons anatomy increase cellular plasticity , and cellular learning , adaptation ... phytocannabinoids from cannabis plant when ingested into man bio mimic endogenous cannabinoids one example - Tetrahydrocannabinolic acid - C22H30O4 358.478 g·mol Anandamide ( narachidonoylethanolamine) C22H37NO2 347.53 g/mol we have identified 150 carbon active phytocannabinoids in the cannabis ( cannabaceae) plant ... each of those have a carbon neutral counter[part
    1