Comments by "Roger Scott Cathey" (@rogerscottcathey) on "The New York Times"
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I believe there are options for prevention and treatment that entail two possible approaches: We know the primary avenue of attack are the lungs, and once in, they attach by means of the spicules or "spikes". Their primary target or "receptor" are the ACE-2 or angiotensin-converting enzymes, same as that of SARS-CoV, on the epithelial cells of the lungs. Right there is one strategy for a form of intervention using nebulized or detached bonding receptors, akin to chelators or in fact serpins, serine protease inhibitors.
Beside Remdesivir, Pyridone type, and specifically an alpha-ketomide inhibiting compound "13b" will likely emerge as promising along these lines within the body. This compound disables the sars-cov-2 cleavage enzyme on the attachment spikes (TMPRSS2 transmembrane serine protease).
Since this is a papain-like enzyme, the inhibitor will not affect the human serine enzymes, like trypsin, amylase, etc.
It could be used externally as well to attach aerosolized virii and they'll be inactivated even if they are inhaled.
Paper on Alpha-ketomide inhibitor Compound 13b:
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors
Linlin Zhang
Daizong Lin
Xinyuanyuan Sun
Ute Curth4, et als.
https://science.sciencemag.org/content/early/2020/03/20/science.abb3405.full
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Another approach is in terms of direct digestion of the virus by hydrolases like amylase, trypsin, chymotrypsin, carboxypetidase, lipase and most importantly RNAase. Intramuscular injections of amylase and trypsin were proven to resolve malaria very effectively by Lambelle in the early part of the 20th c. The ratio of amylase to trypsin was 2:1, and was well tolerated. His paper is available as a link below. While malaria is not a virus, the process of infectant inhibition of native enzymes taxing the whole system is akin and the strategy of bolstering it is rational. Futhermore the glycoprotein of the viral spike is very susceptible to degradation by amylase which enables full access of the pancreatic proteases or their serum analogs.
It is worthwhile to also research the potential of external nebulized colloidal silver in air systems and bound to fiber masks, as an effective means of external denaturing the virus. As for inhaled nebulized colloidals, I am aware of only one article on an inhalant or in nebulized form:
Journal of Nutritional & Environmental Medicine:
Viral Pathogens and Severe Acute Respiratory Syndrome: Oligodynamic Ag+ for Direct Immune Intervention
Eric Rentz Do Comm Cnmo
https://www.tandfonline.com/doi/abs/10.1080/13590840310001594061
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For structure of viral components, also see:
Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein
Authors:
Alexandra C.Walls
David Veesler
https://www.sciencedirect.com/science/article/pii/S0092867420302622
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A transcription I did of Dr. Lambelle's paper on malaria treatment using amylase and trypsin is available at a mirror of my old website:
https://robertcathey.wordpress.com/the-utility-of-enzymes-in-malaria-by-f-w-lamballe-m-b-major-royal-army-medical-corps/
Lambelle, F. W. (1913). Journ. R.A.M.C., Vol. XXI, p. 660.
John Beard's letter to Nature re Dr. Lambelle's work. (The transcriptionist at Nature misspelled Lambelle as "Lamballe".)
https://www.nature.com/articles/092060c0
(edit 4/9/2020)
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